The syntheses, structures, and chemotherapeutic activities of Ag(I)-, Au(I)-, and Ru(II)-complexes ligated to a novel N-heterocyclic carbene ligand, 2-(4nitrophenyl)imidazo[1,5-a]pyridin-2-ylidene (1), are described. The corresponding complexes, [Ag (1) Cl][PF 6 ] (4), were prepared using convenient transmetallation chemistry and characterized using a range of spectroscopic and analytical techniques. X-ray crystallography revealed that complexes 2 and 3 adopted linear structures whereas 4 exhibited a prototypical "piano-stool"-like geometry; the structural assignments were further supported by DFT calculations. A series of in vitro studies revealed that while the aforementioned Ag(I), Au(I) and Ru(II) complexes exhibited significant cytotoxicities against the human colon adenocarcinoma (HCT 116), lung cancer (A549), and breast cancer (MCF7) cell lines, the Ru derivative was most prominent.
A series of silver(I) and gold(I) carbene complexes of the type [M(L)(2,2′‐bipyridine)][PF6] (L = 1‐benzyl‐3‐(2‐pyridylmethyl)benzimidazolylidene; M = Ag (1); M = Au (3)) and [M(L)(carbazole)] (M = Ag (2); M = Au (4)) were synthesized and analyzed using a range of spectroscopic and crystallographic techniques. Inspection of the solid‐state structures of 1, 2 and 4 revealed a number of intermolecular noncovalent interactions. In the solid‐state structure adopted by 1, π–π and Ag–Ag interactions directed the complexes to orient in a head‐to‐tail fashion. The photophysical properties were found to be influenced by the ancillary ligands in solution as well as in the solid‐state. Calculations were performed to support the aforementioned structural and optoelectronic assignments.
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