A novel Au(III)–N-heterocyclic
carbene organometallic complex
supported by two N-heterocyclic carbene (NHC) ligands was synthesized
from Au(SMe2)Cl and 1-methyl-2-pyridin-2-yl-2H-imidazo[1,5-a]pyridin-4-ylium hexafluorophosphate
via a Ag intermediate. X-ray crystallography revealed the first example
of a square planar geometry adopted by a Au(III) species stabilized
by two NHCs and two chloride ligands. The aforementioned Au(I)–
and Au(III)–NHC complexes were found to be more potent than
cisplatin against the HCT 116, HepG2, A549, and MCF7 cell lines.
Cl–Ag(i)–NHC, Cl–Au(i)–NHC, and Cl3–Au(i)–NHC complexes based on the 1-methyl-2-pyridin-2-yl-2H-imidazo[1,5-a]pyridin-4-ylium chloride, were tested for their cytotoxicity towards different cancer cell lines.
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