BACKGROUND AND OBJECTIVES: Neuropathic pain is a complex, painful condition, difficult to diagnose and treat with a negative impact on patients' health and quality of life. The objective of this study was to evaluate the correlation between pain and quality of life, identifying the limiting aspects in the daily life of these individuals, so that patient education is recommended in the management of this condition. METHODS: This is a descriptive, cross-sectional study conducted in a Pain Clinic with 61 patients diagnosed with neuropathic pain. The tools used to assess the quality of life were a semi-structured interview, the Douleur Neuropathique 4 Questions questionnaire, and the World Health Organization Quality of Life-BREF. RESULTS: Of the patients, 57.3% were women, average age 50.6±13.12 years. As for the educational level, 59% attended elementary school, and 61% were married. In 39%, diseases were the main causes of pain and physical problems as the main changes after pain (57%). The majority of patients had a positive attitude towards neuropathic pain (68%). The physical domain was the most impaired in quality of life. All the domains of the quality of life assessment instrument had Cronbach's alpha coefficients (<0.700) with average adherence, especially the general domain, with Cronbach's alpha negative (-0.055). CONCLUSION: Knowing the aspects of the impact of pain on patients' quality of life comes to be a useful scientific resource in the clinical practice and encourages a model of educational intervention where the client is the main subject in managing their painful condition.