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To present the efficacy and safety of Metronidazole and co-trimoxazole in the treatment of diarrhea caused by Entamoeba histolytica, cyst and trophozyed in patients presented to the emergency department and emergency pediatric clinic in Queen Alia Hospital (Jordan). A strategy for diagnosis Entamoeba histolytica was evaluated by studying 181 patients aged 2-50 years. Between the 1st of May 2009 and the beginning of May 2010, 181 patients with intestinal amoebiasis were recruited for this study from the Emergency Department and emergency Pediatric Clinic at Queen Alia Military Hospital. After doing stool analysis for every patient, Metronidazole 500 mg three times was given to the adult group and 40 mg kg -1 day in three divided doses for the pediatric group for 10 days and two tablets twice daily for adults and 5 mL twice daily for children for ten days of co-trimaxazole, with follow up stool analysis after one week of treatment. Out of 181 patients (81) patients were adult's age (14-50 years) and (100 patients) were children aged (2-14 years). About 5.5% of the patient showed the amoebic trophozoite in their stool while the remaining showed only the amoebic cysts. Over all metronidazole and co-trimoxazole produced a clinical response rate of 95% in both adults and children group after 10 days course of Metronidazole. Our findings demonstrated the efficacy of 10 day of course Metronidazole and co-trimoxazole in eradication intestinal amoebiasis for which the causative organism is identified by simple stool examination.

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