Assessment of Lactate Dehydrogenase Levels Among Diabetic Patients Treated in the Outpatient Clinics at King Hussein Medical Center, Royal Medical Services, Jordan

Dmour, Asem Hussein H.; Khreisat, Eman F.; Khreisat, Amal F.; Hasan, Shereen Abdullah; Atoom, Osama; Alkhatib, Ahed J

doi:10.5455/medarh.2020.74.384-386

Cited by 15 publications

(8 citation statements)

References 19 publications

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“…The overall mean LDH levels were found to be 323.84 ± 26.68 U/L while the normal reference range is 140-280 U/L. This signifies that a raised LDH level is an adverse outcome of prediabetes which was in accordance with the study conducted by Dmour et al [9] who found the same correlation in type 2 diabetic patients. Tanada et al [10] in their study observed a rise in serum LDH activity with an increase in exercise which was in accordance with our study.…”

Section: Discussionsupporting

confidence: 89%

Is there any correlation between muscle fatigue and serum lactate dehydrogenase levels in prediabetic individuals?

Mishra

Ailani

Saxena³

et al. 2022

Exploration of Medicine

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Aim: Lactate dehydrogenase (LDH) is an enzyme that acts as a catalyst in the conversion of lactate to pyruvate which is abundantly found in liver, kidney, heart and muscles. Previous studies have all shown a strong positive correlation between muscle fatigue and increased serum LDH levels with type 2 diabetes mellitus but no study has actually assessed the same for prediabetes. The basic objective of this study, thus, is to find out the correlation between muscle fatigue and serum LDH levels in prediabetic individuals. Methods: A cross-sectional study was conducted in adults between 24–60 years old who were classified as prediabetic individuals as per norms established by American Diabetes Association. A total of 100 prediabetic individuals were selected for the study. Fatigability was calculated as a function of work done by the pleximeter finger of the dominant hand using Mosso’s ergograph. The study was conducted at Rajarshi Dashrath Autonomous State Medical College, Ayodhya. Results: Out of 100 prediabetic participants, 50% were males with a mean age of 44.14 ± 10.91 years and remaining 50% were females with a mean age of 41.12 ± 11.5 years. Overall, the average work done by the participants was 2.9 ± 1.2 weight lifted•total distance moved (kg•m) with an average serum LDH level of 323.84 ± 26.82 unit/litre (U/L). Conclusions: This study aimed at assessing the correlation between muscle fatigue and serum LDH levels in prediabetic individuals so that further work can be initiated to improve the quality of life in prediabetics that maybe drastically hampered due to easy fatigability in prediabetic individuals.

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Section: Discussionsupporting

confidence: 89%

Is there any correlation between muscle fatigue and serum lactate dehydrogenase levels in prediabetic individuals?

Mishra

Ailani

Saxena³

et al. 2022

Exploration of Medicine

View full text Add to dashboard Cite

show abstract

“…LDH is elevated in a variety of disorders due to its widespread activity in body (Klein et al, 2020). Normal range of LDH is 140-280 IU/L (Dmour et al, 2020). Results of this study have shown that there is nonsignificant difference between smokers and non-smokers.…”

Section: Discussionmentioning

confidence: 59%

Effect of cigarette smoking on blood biochemical parameters in males of district Swabi, Khyber Pakhtunkhwa, Pakistan

Rukhsana

Riaz

Khalid

2022

Nat. App. Sci. Int. J.

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Smoking is one of the most common preventable causes of mortality worldwide. It increases the risk of cardiovascular diseases by affecting lipid profiles and diabetes by elevating blood glucose levels. To investigate the injurious effect of cigarette smoking, the present study was done in the tehsil Topi of district Swabi. The study aimed to find an association between cigarette smoking and liver function, cardiovascular diseases, and diabetes. About 100 healthy males were selected, ranging from 20 to 35. They were divided into two groups, 50 were smokers, and 50 were non-smokers. Blood samples were taken to estimate serum liver function test and blood glucose levels. Serum Alkaline Phosphatase (ALP) in smokers was increased by 12% (P < 0.05) in comparison to non-smokers. At the same time, Aspartate Aminotransferase (AST) was increased by 17% (P > 0.05) for smokers as compared to non-smokers. Lactate Dehydrogenase showed a 4% (P > 0.05) increase in smokers. Blood glucose levels showed elevation by 7% (P < 0.05) in smokers. The study concluded that the injurious health effects of cigarette smoking increase with an increase in the number of cigarettes smoked in a day. It can affect blood glucose levels putting cigarette smokers at high risk of diabetes.

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“…In most kinds of cells, glycolysis is activated in diabetes [ 109 ], but unlike aerobic glycolysis, relatively few is information about changes in anaerobic glycolysis in diabetes [ 110 ]. In diabetic patients, a marked increase in the lactate dehydrogenase activity [ 111 , 112 ] and the amount of lactate leading to local acidification [ 113 , 114 , 115 , 116 ] is observed compared to the healthy control group. Earlier results approved that increased lactate levels are an independent risk factor for the T2DM development [ 110 , 117 ], but further data suggests that lactate is not enough to induce insulin resistance in humans [ 118 ].…”

Section: Discussionmentioning

confidence: 99%

The WWOX/HIF1A Axis Downregulation Alters Glucose Metabolism and Predispose to Metabolic Disorders

Baryła

Styczeń-Binkowska

Płuciennik

et al. 2022

IJMS

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Recent reports indicate that the hypoxia-induced factor (HIF1α) and the Warburg effect play an initiating role in glucotoxicity, which underlies disorders in metabolic diseases. WWOX has been identified as a HIF1α regulator. WWOX downregulation leads to an increased expression of HIF1α target genes encoding glucose transporters and glycolysis’ enzymes. It has been proven in the normoglycemic mice cells and in gestational diabetes patients. The aim of the study was to determine WWOX’s role in glucose metabolism regulation in hyperglycemia and hypoxia to confirm its importance in the development of metabolic disorders. For this purpose, the WWOX gene was silenced in human normal fibroblasts, and then cells were cultured under different sugar and oxygen levels. Thereafter, it was investigated how WWOX silencing alters the genes and proteins expression profile of glucose transporters and glycolysis pathway enzymes, and their activity. In normoxia normoglycemia, higher glycolysis genes expression, their activity, and the lactate concentration were observed in WWOX KO fibroblasts in comparison to control cells. In normoxia hyperglycemia, it was observed a decrease of insulin-dependent glucose uptake and a further increase of lactate. It likely intensifies hyperglycemia condition, which deepen the glucose toxic effect. Then, in hypoxia hyperglycemia, WWOX KO caused weaker glucose uptake and elevated lactate production. In conclusion, the WWOX/HIF1A axis downregulation alters glucose metabolism and probably predispose to metabolic disorders.

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Assessment of Lactate Dehydrogenase Levels Among Diabetic Patients Treated in the Outpatient Clinics at King Hussein Medical Center, Royal Medical Services, Jordan

Cited by 15 publications

References 19 publications

Is there any correlation between muscle fatigue and serum lactate dehydrogenase levels in prediabetic individuals?

Is there any correlation between muscle fatigue and serum lactate dehydrogenase levels in prediabetic individuals?

Effect of cigarette smoking on blood biochemical parameters in males of district Swabi, Khyber Pakhtunkhwa, Pakistan

The WWOX/HIF1A Axis Downregulation Alters Glucose Metabolism and Predispose to Metabolic Disorders

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