The number of cases has steadily increased over the years since 1985 in Turkey. The aim of this study was to evaluate the epidemiological and clinical characteristics of HIV/AIDS cases in our province. Data on 202 HIV/AIDS cases diagnosed between January 1993 and December 2015 in Mersin were obtained from patient files. A total of 202 HIV/AIDS cases, 158 (78.2%) males, were included in the study. 136 (67.3%) of the cases were in the 24-44 age range. 198 (98.0%) of the cases were Turkish citizens and 115 cases (40.1%) had social security 66 cases (32.6%) are the most common workers. The highest risk factor was risky sexual intercourse with 16 (7.9%) cases. While the incidence of HIV/AIDS was 2.0 per hundred thousand in 2000, it was found that this rate increased to 10.9 per hundred thousand in 2015. Opportunistic infections were detected during the AIDS phase. When the patients applied for the first time, the mean number of CD4+ T lymphocyte cells was greater than> 500 in 39 (19.3%). Viral load rates are in the range of <10000 in 49 (24.3%). 59 (29.2%) cases received anti-retroviral therapy. During the study 11 (5.4%) of the cases died. In our region, the incidence of HIV/AIDS has been increasing over the years. Risk factors of cases have not been reached to a large extent. Risk factors are  determined in the shortest time and education and health services should be planned to combat this disease.

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