BackgroundSedentary work is hazardous. Over 80% of all US jobs are predominantly sedentary, placing full‐time office workers at increased risk for cardiovascular and metabolic morbidity and mortality. Thus, there is a critical need for effective workplace physical activity interventions. MapTrek is a mobile health platform that gamifies Fitbit use for the purpose of promoting physical activity. The purpose of this study was to test the efficacy of MapTrek for increasing daily steps and moderate‐intensity steps over 10 weeks in a sample of sedentary office workers.Methods and ResultsParticipants included 146 full‐time sedentary office workers aged 21 to 65 who reported sitting at least 75% of their workday. Each participant received a Fitbit Zip to wear daily throughout the intervention. Participants were randomized to either a: (1) Fitbit‐only group or 2) Fitbit + MapTrek group. Physical activity outcomes and intervention compliance were measured with the Fitbit activity monitor. The Fitbit + MapTrek group significantly increased daily steps (+2092 steps per day) and active minutes (+11.2 min/day) compared to the Fitbit‐only arm, but, on average, participants’ steps declined during the study period.ConclusionsMapTrek is an effective approach for increasing physical activity at a clinically meaningful level in sedentary office workers, but as with accelerometer use alone, the effect decreases over time.Clinical Trial Registration URL: https://www.clinicaltrials.gov. Unique identifier: NCT03109535.

Prolonged sedentary behavior is an independent risk factor for multiple negative health outcomes. Evidence supports introducing standing desks into K-12 classrooms and work settings to reduce sitting time, but no studies have been conducted in the college classroom environment. The present study explored the acceptability and feasibility of introducing standing desks in college classrooms. A total of 993 students and 149 instructors completed a single online needs assessment survey. This cross-sectional study was conducted during the fall semester of 2015 at a large Midwestern University. The large majority of students (95%) reported they would prefer the option to stand in class. Most students (82.7%) reported they currently sit during their entire class time. Most students (76.6%) and instructors (86.6%) reported being in favor of introducing standing desks into college classrooms. More than half of students and instructors predicted having access to standing desks in class would improve student’s “physical health”, “attention”, and “restlessness”. Collectively, these findings support the acceptability of introducing standing desks in college classrooms. Future research is needed to test the feasibility, cost-effectiveness and efficacy of introducing standing desks in college classrooms. Such studies would be useful for informing institutional policies regarding classroom designs.

Relative burst amplitude of muscle sympathetic nerve activity (MSNA) is an indicator of augmented sympathetic outflow and contributes to greater vasoconstrictor responses. Evidence suggests anxiety-induced augmentation of relative MSNA burst amplitude in patients with panic disorder; thus we hypothesized that acute stress would result in augmented relative MSNA burst amplitude and vasoconstriction in individuals with chronic anxiety. Eighteen participants with chronic anxiety (ANX; 8 men, 10 women, 32 ± 2 yr) and 18 healthy control subjects with low or no anxiety (CON; 8 men, 10 women, 39 ± 3 yr) were studied. Baseline MSNA and 24-h blood pressure were similar between ANX and CON ( P > 0.05); however, nocturnal systolic blood pressure % dipping was blunted among ANX ( P = 0.02). Relative MSNA burst amplitude was significantly greater among ANX compared with CON immediately preceding (anticipation) and during physiological stress [2-min cold pressor test; ANX: 73 ± 5 vs. CON: 59 ± 3% arbitrary units (AU), P = 0.03] and mental stress (4-min mental arithmetic; ANX: 65 ± 3 vs. CON: 54 ± 3% AU, P = 0.02). Increases in MSNA burst frequency, incidence, and total activity in response to stress were not augmented among ANX compared with CON ( P > 0.05), and reduction in brachial artery conductance during cold stress was similar between ANX and CON ( P = 0.92). Relative MSNA burst amplitude during mental stress was strongly correlated with state ( P < 0.01) and trait ( P = 0.01) anxiety (State-Trait Anxiety Inventory), independent of age, sex, and body mass index. Thus in response to acute stress, both mental and physiological, individuals with chronic anxiety demonstrate selective augmentation in relative MSNA burst amplitude, indicating enhanced sympathetic drive in a population with higher risk for cardiovascular disease. NEW & NOTEWORTHY Relative burst amplitude of muscle sympathetic nerve activity in response to acute mental and physiological stress is selectively augmented in individuals with chronic anxiety, which is a prevalent condition that is associated with the development of cardiovascular disease. Augmented sympathetic burst amplitude occurs with chronic anxiety in the absence of common comorbidities. These findings provide important insight into the relation between anxiety, acute stress and sympathetic activation.

Elevated muscle sympathetic nerve activity (MSNA) is associated with the pathogenesis of hypertension and cardiac arrhythmias, and may be related to greater cardiovascular disease (CVD) risk among individuals with chronic anxiety. Augmented sympathetic responsiveness in chronic anxiety may potentially be attributed to alteration in sympathetic baroreflex control. We hypothesized that MSNA and its responsiveness to stress would be augmented in chronic anxiety, and that augmented MSNA responsiveness would be related to impaired sympathetic baroreflex sensitivity. Sympathetic baroreflex sensitivity was assessed by relating spontaneous changes in multi‐unit MSNA to beat‐to‐beat changes in diastolic blood pressure (DBP) using a weighted linear regression at rest (10 min) and during mental stress (MS, 4‐min mental arithmetic) in 18 individuals with moderate/high chronic anxiety (ANX, 6 men/12 women; 32±2 yrs; 27±2 kg/m2) who were nonsmokers and free of CVD, and in 18 healthy controls with low/no anxiety (CON, 8 men/10 women; 39±3 yrs; 30±1 kg/m2). Resting MSNA was not elevated among ANX compared to CON (MSNA burst incidence: ANX 29 ± 5 vs. CON 40 ± 4 bursts/100hb; Avg. relative MSNA burst amplitude: ANX 48 ± 1 vs. CON 47 ± 1 AU). Avg. relative MSNA burst amplitude in response to MS was significantly augmented among ANX compared to CON (ANX: 61 ± 2 vs. CON: 54 ± 2 AU, P=0.02), while % change in MSNA burst incidence was not significantly different between ANX and CON (ANX: 4 ± 7 vs. CON: 6 ± 7 bursts/100hb, P=0.86). Increases in avg. relative MSNA burst amplitude during MS were significantly correlated with trait anxiety score among all participants after adjusting for age, sex, and BMI (R=0.48, P=0.01). The slope between MSNA burst incidence and DBP was not different between ANX and CON at rest (ANX: −2.8 ± 0.6 vs. CON: −3.5 ± 0.5 bursts/100hb/mmHg−1, P=0.35), and was significantly reduced during MS (P=0.03) with no difference between ANX and CON (ANX: −2.2 ± 0.4 vs. CON: −2.3 ± 0.5 bursts/100hb/mmHg−1, P=0.42). The slope between total MSNA and diastolic BP was similar between ANX and CON at rest (ANX: −1.5 ± 0.3 vs. CON: −1.9 ± 0.3 AU/beat/mmHg−1, P=0.3) and unchanged (P=0.49) during MS (ANX: −1.5 ± 0.3 vs. CON: −1.5 vs. 0.3 AU/beat/mmHg−1, P=0.99). These preliminary findings demonstrate that individuals with chronic anxiety exhibit augmented increases in MSNA burst amplitude but not burst incidence to mental stress, and this alteration in the MSNA response to mental stress in chronic anxiety is not a result of impairment in sympathetic baroreflex sensitivity.Support or Funding InformationAHA 17POST33440101, T32 HL07121 NHLBI (P01HL014388), U54 TR001356 and AHA (13DG143400012)This abstract is from the Experimental Biology 2018 Meeting. There is no full text article associated with this abstract published in The FASEB Journal.

The age-related increase in aortic stiffness increases systolic blood pressure (BP) and flow pulsatility and is associated with target organ damage such as ischemic cerebrovascular disease. However, the mechanistic link between aortic stiffness and cerebrovascular disease remains unclear because techniques available to non-invasively assess dynamic changes in the human brain microcirculation with high spatial and temporal resolution are limited. Given the evidence that disease- and age- related alterations in the retinal microvasculature may mirror changes in the cerebral microvasculature, we assessed resting and dynamic changes in the retinal microcirculation using high resolution laser speckle flowgraphy. We tested the hypothesis that retinal microvascular blood flow at rest and during acute increases in BP would be associated with age-related increases in aortic stiffness (carotid-femoral pulse wave velocity, CFPWV). In 40 healthy subjects (35 ± 2 years; 25-60 years; 18 M/22 F; systolic BP: 123 ± 2 mmHg; diastolic BP: 77 ± 2 mmHg), retinal arterial blood flow was assessed at baseline (following dilation of the left pupil with 0.5% topicamide), and during a sympatho-excitatory stimulus (2-min cold pressor test). At baseline, lower retinal blood flow was significantly correlated with higher CFPWV (R=-0.35, P=0.03) and older age (R=-0.38, P=0.02) independent of mean BP (partial correlation). In response to the CPT, significant increases were observed in mean BP (BL: 92 ± 2 vs. CPT: 106 ± 2 mmHg, P<0.001) and retinal blood flow (BL: 215 ± 6 vs. CPT: 230 ± 8 AU, P<0.001). The relation between higher CFPWV and lower retinal blood flow observed at baseline was maintained during the CPT independent of mean BP (R=-0.37, P=0.03). However, no association was noted between CFPWV and % change in retinal blood flow. These preliminary data suggest that higher aortic stiffness is associated with lower retinal microvascular blood flow at rest and during sympatho-excitation independent of BP. These findings have important implications for age-related ocular degeneration, and lend support for future studies aiming to identify retinal microvascular abnormalities as markers of age-related cerebrovascular pathology.

The health benefits of regular physical activity are well known and include the prevention of chronic diseases such as obesity, type 2 diabetes, and cardiovascular diseases. Still, only 20% of U.S. adults report meeting the Physical Activity Guidelines for Americans. With approximately 43% of U.S. jobs considered sedentary, there is a need for effective workplace physical activity interventions. MapTrek is a mobile health game designed to increase daily physical activity in a low-cost, scalable, and enjoyable way. The purpose of the present study was to test the efficacy of MapTrek for increasing daily steps and moderate-intensity steps over 10 weeks in a sample of sedentary office workers. Participants included 144 full-time sedentary office workers ages 21-65 who reported sitting at least 75% of their workday. Each participant received a Fitbit Zip to wear daily throughout the intervention. Participants were randomized to either a: 1) Fitbit only group or 2) Fitbit + MapTrek group. Physical activity outcomes and intervention compliance were measured with the Fitbit activity monitor. The Fitbit + MapTrek group significantly increased daily steps (+2,091.5 steps/day) and active minutes (+11.2 minutes/day) compared to the Fitbit only arm. These data support MapTrek as an effective approach for increasing physical activity at a clinically meaningful level in sedentary office workers.