Relative burst amplitude of muscle sympathetic nerve activity is an indicator of altered sympathetic outflow in chronic anxiety

Holwerda, Seth W.; Luehrs, Rachel E; Gremaud, Allene L.; Wooldridge, Nealy A; Stroud, Amy; Fiedorowicz, Jess G.; Abboud, François M.; Pierce, Gary L.

doi:10.1152/jn.00064.2018

Cited by 52 publications

(57 citation statements)

References 67 publications

(81 reference statements)

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“…Multiunit postganglionic MSNA was recorded from the peroneal nerve using standard microneurographic techniques as described in previous studies [35][36][37][38] and in the Online Data Supplement. Plasma norepinephrine concentration was assessed using high performance liquid chromatography.…”

Section: Sympathetic Nerve Activitymentioning

confidence: 99%

Elevated Muscle Sympathetic Nerve Activity Contributes to Central Artery Stiffness in Young and Middle-Age/Older Adults

Holwerda¹,

Luehrs²,

DuBose

et al. 2019

Hypertension

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Muscle sympathetic neural activity (MSNA) influences the mechanical properties (i.e., vascular smooth muscle tone and stiffness) of peripheral arteries, but it remains controversial whether MSNA contributes to stiffness of central arteries such as the aorta and carotids. We examined whether elevated MSNA (age-related) would be independently associated with greater stiffness of central [carotid-femoral pulse wave velocity (PWV)] and peripheral (carotid-brachial PWV) arteries, in addition to lower carotid compliance coefficient (CC), in healthy men and women (n=88, age:19-73 years, 52%men). Also, we examined whether acute elevations in MSNA without increases in mean arterial pressure (MAP) using graded levels of lower body negative pressure (LBNP) would augment central and peripheral artery stiffness in young (YG, n=15, 60%men) and middle-age/older adults (MA/O, n=14, 43%men). Resting MSNA burst frequency (bursts•min −1) was significantly correlated with carotid-femoral PWV (R=0.44, P<0.001), carotid-brachial PWV (R=0.32, P=0.003), and carotid CC (R=0.28, P=0.01) after controlling for sex, MAP, heart rate, and waist-to-hip ratio (central obesity), but these correlations were abolished after further controlling for age (all P>0.05). In YG and MA/O adults, MSNA was elevated during LBNP (P<0.001) and produced significant increases in carotid-femoral PWV (YG:Δ+1.3±0.3 vs. MA/ O:Δ+1.0±0.3 m•s −1 , P=0.53) and carotid-brachial PWV (YG: Δ+0.7±0.3 vs. MA/O: Δ+0.7±0.5 m•s −1 , P=0.92), whereas carotid CC during LBNP was significantly reduced in YG but not MA/O (YG:Δ-0.04 ±0.01 vs. MA/O:Δ0.001±0.008 mm 2 •mmHg −1 , P<0.01). Collectively, these data demonstrate the influence of MSNA on central artery stiffness and its potential contribution to age-related increases in stiffness of both peripheral and central arteries.

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Section: Sympathetic Nerve Activitymentioning

confidence: 99%

Elevated Muscle Sympathetic Nerve Activity Contributes to Central Artery Stiffness in Young and Middle-Age/Older Adults

Holwerda¹,

Luehrs²,

DuBose

et al. 2019

Hypertension

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“…Monocytes have been shown to be responsive to social isolation 29 and anxiety 28 . Social isolation and anxiety, produced by Western diet consumption, may be accompanied by increased sympathetic outflow and increased hypothalmic-pituitary adrenal production of cortisol, both of which modulate monocyte intracellular processes governing inflammatory molecule production [74][75][76] . Supporting the involvement of these systems, we previously reported that the Western diet group had increased sympathetic activity, and increased cortisol concentrations 77 .…”

Section: Discussionmentioning

confidence: 99%

“…Monocytes have been shown to be responsive to social isolation (Cole, 2019) and anxiety (Cole et al, 2015). Social isolation and anxiety, produced by Western diet consumption, may be accompanied by increased sympathetic outflow and increased hypothalamic-pituitary adrenal production of cortisol, both of which modulate monocyte intracellular processes governing inflammatory molecule production (Cacioppo et al, 2015; Holwerda et al, 2018; Juruena et al, 2020).…”

Section: Discussionmentioning

confidence: 99%

Contrasting Effects of Western vs. Mediterranean Diets on Monocyte Inflammatory Gene Expression and Social Behavior in a Primate Model

Johnson

Shively

Michalson

et al. 2020

Preprint

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23Summary 24Monocytes and macrophages-important mediators of innate immunity, health, and disease-are 25 sensitive to diet and stress. Western diets promote inflammation and disease, while 26Mediterranean diets reduce inflammation and promote health, although the mechanisms through 27 which diet alters immune function are unknown. Here, we conducted the first randomized, long-28 term diet trial in which macaques were fed either a Western-or Mediterranean-like diet to 29 determine how diet and behavior interact to influence monocyte polarization-a precursor to 30 subsequent health outcomes. Monocyte gene expression profiles differed markedly between the 31 two diets, with over 40% of expressed genes being differentially expressed (FDR<0.05). The 32Western diet induced a more proinflammatory monocyte phenotype with changes in monocyte 33 polarization-associated genes. Diet also shifted the co-expression of gene pairs, including small 34RNAs and transcription factors that are associated with metabolism and adiposity in humans. We 35 also found that diet altered a suite of affiliative and anxiety-associated behaviors, and these 36 behavioral changes mediated ~20% of the effect of diet on monocyte gene expression. Together, 37 these findings suggest that diet-induced effects on monocyte polarization are due, in part, to both 38 direct and behaviorally-mediated effects on monocyte gene expression. 39

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“…With larger sample sizes it may be possible to explore these mechanisms and also divide individuals into groups of positive, negative and nonresponders, that is, those with a mean change in MSNA burst frequency of <3 bursts/min during mental stress. Evidence suggests that anxiety disorders may be associated with augmented sympathetic activity during stress when compared with healthy controls (Park et al 2017;Holwerda et al 2018b). Park et al (2017) reported an overall increase in MSNA during mental stress, which was exaggerated in those with post-traumatic stress disorder (PTSD).…”

Section: Future Directionsmentioning

confidence: 99%

Blood pressure reactivity at onset of mental stress determines sympathetic vascular response in young adults

et al. 2018

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We have previously shown in young males that the rate of rise in blood pressure (BP) at the onset of mental stress determines whether or not muscle sympathetic nerve activity (MSNA) has a role in driving the pressor response. The aim of this study was to investigate these interactions in young females. BP and MSNA were recorded continuously in 19 females and 21 males during 2‐min mental stressors (mental arithmetic and Stroop test). Physical stressor tasks (cold pressor, handgrip exercise, postexercise ischemia) were also performed. During the first minute of mental arithmetic, the rate of rise in mean arterial pressure (MAP) was significantly greater in negative responders (mean decrease in MSNA) compared with positive responders (mean increase in MSNA) in both males (1.9 ± 0.7 vs. 0.7 ± 0.3 mmHg/sec) and females (1.0 ± 0.3 vs. 0.5 ± 0.2 mmHg/sec). For the Stroop test, there was no significant difference in the rate of the rise in BP between positive and negative responders (P > 0.05). However, peak changes in MAP were significantly greater in negative responders compared with positive responders in both males (22 ± 6 vs. 13 ± 3 mmHg) and females (12 ± 2 vs. 6 ± 1 mmHg). Sympathetic baroreflex sensitivity was greater in negative responders and may contribute to the fall in MSNA experienced by these individuals during mental stress. During physical stressors there were consistent increases in BP and MSNA in males and females. The findings suggest that, in both males and females, BP reactivity at the onset of mental stress dictates whether or not there is an increase or decrease in MSNA.

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Relative burst amplitude of muscle sympathetic nerve activity is an indicator of altered sympathetic outflow in chronic anxiety

Cited by 52 publications

References 67 publications

Elevated Muscle Sympathetic Nerve Activity Contributes to Central Artery Stiffness in Young and Middle-Age/Older Adults

Elevated Muscle Sympathetic Nerve Activity Contributes to Central Artery Stiffness in Young and Middle-Age/Older Adults

Contrasting Effects of Western vs. Mediterranean Diets on Monocyte Inflammatory Gene Expression and Social Behavior in a Primate Model

Blood pressure reactivity at onset of mental stress determines sympathetic vascular response in young adults

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