Background: Asthma is a chronic inflammatory lung disease and oxidative stress is an important component in airway inflammation. This study aims to investigate dynamic thiol/disulfide homeostasis in patients with asthma. Methods: A total of 103 subjects, including 56 patients with asthma and 47 healthy controls, of similar age and gender were included in the study. The native thiol, total thiol and disulfide levels and the disulfide-native thiol, disulfide-total thiol and native thiol-total thiol ratios were analyzed and compared between the asthma and control groups using a novel automatized spectrophotometric assay. Results: The levels of native thiol (p<0.001), total thiol (p<0.001) and disulfide (p<0.001) were significantly lower and the C-reactive protein (CRP) levels (p<0.001) were significantly higher in patients with asthma when compared with those in the control group. A negative correlation was detected between CRP levels and native thiol, total thiol and disulfide levels (p<0.05). A significant positive correlation was detected between forced expiratory volume in 1 s (FEV1) and forced vital capacity (FVC) levels and native thiol and total thiol levels (p<0.01). Conclusions: The thiol/disulfide homeostasis parameters may be used as novel oxidative stress markers in asthma but further studies are needed to investigate the role of thiol/disulfide homeostasis in asthma.
Objective: While the effects of obesity on asthma are unclear, an increased body mass index (BMI) is known to enhance the symptoms and severity of asthma and to impair asthma control. The present study evaluates the effects of nutritional habits and obesity on pulmonary function and asthma control in individuals with asthma. Methods: This cross-sectional study included 60 obese respondents and 60 respondents with normal body weight, who were referred to pulmonology clinics over a period of 2 months. The anthropometric measurements and macro–micro nutrient consumption records of the patients in both groups were obtained, and the two groups were compared in terms of pulmonary function and asthma control test (ACT) scores. Results: The mean age of the normal weight and obese respondents was 39.55 ± 11.0 and 45.1 ± 10.3 years, respectively. The ACT scores of the respondents decreased significantly with increasing BMI, waist circumference (WC), and waist–hip ratio (WHR) measurements ( P < 0.05). The obese respondents had a lower mean forced vital capacity (FVC), forced expiratory volume in 1 s (FEV 1 ), midexpiratory flow (MEF) between 25% and 75% of the maximal expiration (MEF 25–75 ), MEF 75 , MEF 50 , MEF 25 , and FEV 1 /FVC values when compared to the respondents with normal weight ( P < 0.05). The total energy and carbohydrate intake was higher in the obese respondents, while their total protein intake was lower when compared to the normal weight respondents ( P < 0.05), and a significant positive correlation was found between the omega 3 intake and ACT scores of the respondents ( P < 0.05). Conclusions: Pulmonary functions and ACT scores decrease with increasing BMI, WC, and WHR. Obese respondents with asthma should be referred to diet clinics to improve their asthma symptoms.
Amaç: Pulmoner tromboemboli, mortalitesi ve morbiditesi yüksek olan bir hastalıktır. Bu çalışmada serum sodyum, glukoz ve kreatinin değerlerinin prognoz üzerine olan etkileri araştırılmıştır. Hastalar ve Yöntemler: Ocak 2010 ile Aralık 2012 tarihleri arasında PTE tanısı ile yatırılarak tedavi edilen hastaların verileri retrospektif olarak incelendi. Başvuru anındaki rutin laboratuvar değerleri, arteriyel kan gazı ve transtorasik ekokardiyografi sonuçları ile 30 günlük mortalite oranları kaydedildi. Bulgular: Her iki grup karşılaştırıldığında mortalitesi yüksek olan grubun ortalama serum sodyum düzeyi ve eGFR, diğer gruba göre anlamlı olarak daha düşükken, serum glukoz düzeyi daha yüksek saptandı. Bu belirteçlerin PESI ile uyumluluğu incelendiğinde ise PESI sınıf V'de diğer sınıflara göre serum sodyum düzeyinin ve eGFR'nin daha düşük, serum glukoz düzeyinin daha yüksek olduğu saptandı ve bu fark istatistiksel olarak anlamlı bulundu. Sonuç: Çalışmamızda, her merkezde kolaylıkla uygulanabilme avantajına sahip parametreler olan serum sodyum, glukoz ve eGFR düzeylerinin, akut PTE'de mortalite riskini belirlemede, daha önce etkinliği kanıtlanmış prognostik faktörler olan RVD, troponin ve PESI parametreleri ile uyumluluk gösterdikleri saptandı.
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