Assessment of dynamic thiol/disulfide homeostasis in patients with asthma

Nar, Rukiye; Çalış, Aliye Gamze

doi:10.1515/labmed-2017-0144

Cited by 6 publications

(1 citation statement)

References 34 publications

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“…This oxidation-reduction cycle between the thiol and DS groups ensures the maintenance of a dynamic thiol-disulfide balance, which is essential for several physiological processes, including, but not limited to, cell signaling, xenobiotics detoxification and antioxidant defense [10,11]. Recent studies have demonstrated that changes in the thioldisulfide balance are associated with the etiology and/or progression of various diseases [12][13][14][15]. This study aims to investigate the effects of smoking on dynamic thiol-disulfide balance in healthy individuals.…”

Section: Introductionmentioning

confidence: 99%

The thiol-disulfide balance in smokers and non-smokers

Çakırca¹

2019

Ann Clin Anal Med

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Aim: The impairment of thiol/disulfide balance plays a critical role in the development and/or progression of many diseases. This study aims to investigate the effects of smoking on dynamic thiol-disulfide balance as a marker of oxidative stress in healthy individuals. Material and Method: The study included 30 smoking and 30 non-smoking healthy individuals. The age, gender, body mass index (BMI) and smoking habits of all of the participants were recorded, and thiol-disulfide balance tests, including total thiol (TT), native thiol (NT) and disulfide (DS), were determined using a novel colorimetric method. Results: The TT and NT levels of the smokers were significantly lower than those of the non-smokers, whereas there were no significant differences in the DS levels and DS/NT, DS/TT and NT/TT ratios of the two groups. In the smoking group, BMI was negatively correlated with NT and TT levels and NT/TT ratio and positively with DS/ NT and DS/TT ratios. Age was negatively correlated with NT and TT levels in the smokers. Discussion: Our findings demonstrated that NT and TT levels were reduced in smokers. We believe that supplementation of thiol-containing compounds may diminish the harmful effects of smoking by preventing or alleviating smoking-induced oxidative stress.

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Section: Introductionmentioning

confidence: 99%

The thiol-disulfide balance in smokers and non-smokers

Çakırca¹

2019

Ann Clin Anal Med

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The effect of thiol/disulfide homeostasis on chronic obstructive pulmonary disease-related mortality

Çalışkan¹,

Ilanbey²,

Zorlu³

et al. 2021

Cukurova Medical Journal

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Purpose: Our study investigates the correlation between thiol/disulfide homeostasis and mortality among chronic obstructive pulmonary disease (COPD) patients with hypercapnic respiratory failure (HRF). Materials and Methods: This cross-sectional prospective study comprises a total of 104 subjects, including 64 HRF patients admitted to the Emergency service due to respiratory failure and 40 healthy controls. HRF patients were further divided into two subgroups as those in whom mortality occured after 1 month (n=14), and those who survied (n=50). Thiol/disulfide homeostasis was evaluated using a novel and automated assay developed by Erel and Neselioglu. Results: The total thiol (TT) and native thiol (NT) levels were significantly lower in the HRF group than the control group, whereas the mean disulfide (Ds)/TT and Ds/NT values were significantly higher. The Ds levels were not significantly different between the groups. On the other hand, Ds, Ds/TT, and Ds/NT values of surviving HRF patients were significantly lower than those of the HRF patients who died. In this article we found that Ds may be an indicator of mortality in COPD (sensitivity: 85.7%, specificity: 70%, AUC: 0.793, 95% CI: 0.673-0.884, p

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Investigation of a Possible Association Between Dynamic Thiol/Disulfide Homeostasis and Pain in Knee Arthroplasty Patients

Sezgin

Ilanbey

2020

Middle Black Sea Journal of Health Science

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Objective: Dynamic thiol/disulfide homeostasis plays a pivotal role in many physiologic mechanisms. In the present study, we aimed to elucidate the relationship between postoperative pain and thiol/disulfide homeostasis in patients who underwent primary total knee arthroplasty for primary knee osteoarthritis. Methods: This prospective uncontrolled study included 28 patients (10 male, 18 female) with a diagnosis of primary gonarthrosis who underwent primary total knee arthroplasty and met the study inclusion criteria. Venous blood samples were taken from the patients and pain values were recorded simultaneously using the visual analog scale (VAS) preoperatively and at the 4th postoperative week. Thiol/disulfide hemostasis levels were measured using a new fully-automated and spectrophotometric method developed by Erel and Neselioglu. Results: The average age of the patients participating in the study was 66.25 ± 8.29 years and 18 (64.3%) of the patients were female. B values for preoperative native/total thiol (+7,652), preoperative disulfide/native thiol (+10,550), and postoperative total thiol (+128), positively affected the difference in VAS values. B values for preoperative disulfide (-219), postoperative disulfide (-1,297), postoperative native/total thiol (-4,238), and postoperative disulfide/native thiol (-3,316) negatively affected the difference in VAS values. Conclusion:The disulfide level, an oxidized form in thiol/disulfide homeostasis, appears to be a valuable marker for evaluating the effect of oxidative stress on postoperative pain.

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Assessment of dynamic thiol/disulfide homeostasis in patients with asthma

Cited by 6 publications

References 34 publications

The thiol-disulfide balance in smokers and non-smokers

The thiol-disulfide balance in smokers and non-smokers

The effect of thiol/disulfide homeostasis on chronic obstructive pulmonary disease-related mortality

Investigation of a Possible Association Between Dynamic Thiol/Disulfide Homeostasis and Pain in Knee Arthroplasty Patients

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