The objective. Decrease the number of diagnostic mistakes of pemphigus vulgaris and late forms of syphilis to improve quality of life and prevent premature death in patients with pemphigus vulgaris. Raise doctors’ awareness of the use of treponemal tests to clarify the diagnosis of late forms of syphilis. Materials and methods. The case of pemphigus vulgaris determined on the basis of clinical picture, anamnesis, cytological examination results is described. A concomitant pathology was diagnosed, i.e., late syphilis due to the complex of serological tests: nontreponemal and treponemal (Venereal Disease Research Laboratory test (VDRL), Enzyme-Linked Immuno Sorbent Assay (ELISA), T. pallidum Haemagglutination Assay (TP-HA), Fluorescent Treponemal Antibody Absorption test (FTA abs), ELISA-Different). Results. At dynamic supervision and inspection of the patient on pemphigus vulgaris and late syphilis on the basis of positive treponemal tests was revealed: ELISA sums. (IgG+IgM) – positive, high-quality TP-HA «4+» – positive; semi-quantitative TP-HA 1: 8 «2+» – positive; FTA abs «3+» – positive. To verify the diagnosis, a serum sample was examined by ELISA-Different method. Conclusions. Due to a wide range of serological research and consultation of related specialists, late syphilis was diagnosed in a pemphigus vulgaris patient.
The article provides an overview of the scientific and medical literature of modern methods of treatment of patients with acantholytic pemphigus. Examples of biological, antiviral, immunological, extracorporeal, local and other therapy of foreign and domestic colleagues are given.
The article presents clinical, cytological, laboratory, histological and immunohistochemical signs of acantholytic pemphigus (AP). Differential diagnostic criteria of dermatoses of various genesis are specified. The data of domestic and foreign authors with the description of clinical cases of AP are presented. Own clinical examples are given. Emphasis is placed on the need for timely diagnosis and appointment of a treatment regimen, which will reduce the proportion of complications, improve the prognosis of the disease and life.
The aim: Determine the clinical and anamnestic criteria that cause the аcantholytic pemphigus (AP) morbidity in the course of the treatment.
Materials and methods: Analysis of medical histories of patients who underwent the therapy on the basis of the clinic for 10 years. In the analysis of 174 medical case histories were determined the factors provoking the onset and exacerbation of the disease. The disease severity was assessed using the IKEDA index.
Results: During the analysis, patients were divided into two groups. The I group - patients who required combination therapy - systemic glucocorticosteroids (SGCs) and immunosuppressant (azathioprine (AZA)). For patients of group II used SGCs - according to the indications. The presence of intoxication and signs of pyoderma were more common in patients of group I. The number of exacerbations per year for an unknown reason in group I was almost 3 times higher. The ineffectiveness of high starting doses of SGCs was 20.2% of cases compared with those in group II.
Conclusions: According to clinical and anamnestic data, during the retrospective analysis of case histories, the criteria determining the severity of acantholytic pemphigus during treatment were determined: the age of patients, the diagnosis period, the prevalence of lesions and severity of dermatosis according to the IKEDA index, the selection of adequate treatment tactics, taking into the complications caused as a result of the systemic glucocorticosteroids therapy.
scite is a Brooklyn-based organization that helps researchers better discover and understand research articles through Smart Citations–citations that display the context of the citation and describe whether the article provides supporting or contrasting evidence. scite is used by students and researchers from around the world and is funded in part by the National Science Foundation and the National Institute on Drug Abuse of the National Institutes of Health.