The aim of the study was to determine the effect of the inhibitor of janus kinase – baricitinib ("Olumiant") on the course of COVID-19. This drug baricitinib is able to suppress the systemic inflammatory response, which is one of the common causes of death in COVID-19, is an urgent problem of the study. The study was carried out in the Regional Specialized Budget Infectious Diseases Hospital of Stavropol (Russian Federation, Stavropol Region). In a multivariate analysis, it was shown that the use of baricitinib was associated with a decrease in the frequency of the primary endpoint of death/need for invasive lung ventilation. The use of baricitinib was quite safe, but in some patients there was an increase in the level of transaminases. No cases of hypercoagulation have been reported while taking baricitinib. It was found that patients with a normal BMI are more sensitive to therapy than those who are overweight.75% of patients in the first group had a temperature above 38.0oC. However, against the background of taking the standard treatment regimen and baricitinib, it was noted that the temperature stabilized during the day and did not rise again. Against the background of taking baricitinib, the elimination of the phenomena of respiratory failure and the refusal of an oxygen mask occurred 3.1 times more often than without baricitinib. The authors concluded that the use of baricitinib can be considered as an additional therapy for moderate forms of pneumonia in patients over 65 years or in patients with concomitant chronic diseases in order to suppress the reactions of systemic inflammation and the development of serious respiratory and other system lesions caused by COVID-19.

At present, research in the field of the brain does not cease to surprise us with new facts and discoveries that no one could have suspected about 30 years ago. But it was at the time when it became clear that the cerebral neurons are not the only cells that can respond to changes in the external environment. A real scientific boom began to study a heterogeneous group called glia. And scientists are paying close attention to the largest of them – astrocytes. Understanding the importance of astrocytes in the mechanisms of repair and damage to brain cells in various forms of CNS pathology determines the possibility of targeted search for drugs that affect the rate of development of reactive astrogliosis in response to various brain injuries. At the same time, pharmacological modulation of activated astrocytes and other components of glia can be an integral part of the therapy of neurological diseases.

In recent years, cases of diseases of the digestive tract among preschool and school-age children have become significantly more frequent. This article analyzes the influence of various factors (heredity, living conditions, age, gender, lifestyle) on the likelihood of morbidity. Chronic pathology of the upper digestive tract in the vast majority of children begins at preschool age with further significant growth from the moment they attend school. Close attention is required by children whose parents and immediate relatives suffer from gastroenterological diseases. Modern diagnosis of the disease will reduce the risk of development and progression of the most common pathology of the digestive organs of childhood and avoid the development of severe complications.

In this paper, the contrasting properties of titanium dioxide nanoparticles in various compositions were considered. In the course of the work, methods for the synthesis of oxide materials SiO2-TiO2, SiO2-ZrO2, TiO2-ZrO2 and SiO2-TiO2-ZrO2 were developed; the microstructure of oxide materials SiO2-TiO2, SiO2-ZrO2, TiO2-ZrO2and SiO2-TiO2-ZrO2was studied; the stability of oxide materials SiO2-TiO2, SiO2-ZrO2, TiO2-ZrO2and SiO2-TiO2-ZrO2 was determined. The elemental composition of the oxide materials SiO2-TiO2, SiO2-ZrO2, TiO2-ZrO2and SiO2-TiO2-ZrO2 has also been studied using SEM and XRD methods. It was found that SiO2-TiO2-ZrO2 nanocomposites with content of titanium dioxide from 8 to 9.5 % and zirconium dioxide from 0.5 to 2 % are completely insoluble in a highly alkaline medium. Thus, this composition is the most optimal for use as a contrast agent in optical coherence tomography.

Homocysteine is a sulfur-containing non-proteinogenic amino acid that is an intermediate product of methionine metabolism. With excessive accumulation of homocysteine in the body, a state of hyperhomocysteinemia occurs, which has attracted the attention of doctors since the middle of the last century and received a serious impetus for research after the publication of data on the role of hyperhomocysteinemia in the pathogenesis of thromboocclusive diseases. To date, there are more than 7.5 thousand scientific papers devoted to the study of hyperhomocysteinemia, monothematic international conferences on clinical and therapeutic aspects of hypermonocysteinemia are held every year. In the Russian Federation, a detailed study of the role of homocysteine and its side effects in excess is of particular interest due to the prevalence of cardiovascular pathologies (according to statistics of the Ministry of Health of Russia-49.27% of deaths of Russians fall on this cohort of diseases). This is an important fact in Russian medicine, which deserves close attention from researchers and scientists.