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Chemical manufacture is a significant value-added industry in both local and global economies. Along with highly relevant issues such as unsustainable process design, energy consumption, and waste generation linked with the sector, societal issues relating to chemical product health and safety are part of the greater sustainability concerns. There is a need to design a sustainable strategy while ensuring economic stability at the corporate level. Hence, this paper presents a methodological proposal of integrated modelling approach for sustainable chemical process design at early design process. The step of achieving this objective is separated into several parts. The first step is to classify parameters from established tools as a benchmark for sustainability metrics. The next step is to transform quantification value of triple bottom line impact (economic, environment and social) to normalized weightage by using Multi Criteria Analysis. The final stage is to develop alternative in terms of technical optimization of process design. The implementation multimodal Multi Criteria Analysis and optimized process design exhibits significant improvements in sustainability impacts according to the waste reduction (WAR) algorithm.

The sustainability weighting is crucial as it is practically implemented into sustainability evaluation, especially in industrial development. Sustainability is about the interconnection between three aspects of sustainability impact such as economic impact, environmental impact, and social impact. Multi-Criteria Analysis (MCA) model play important roles to measure the weighting for each impact according to the scenario and criteria selected based on scientific rules and robust statistical methods. However, there were insufficient studies on the existing literature sustainability weighting model from MCA method for the ethanol plant. Hence, the present paper demonstrates a systematic literature review of MCA model methods on sustainability weighting for the ethanol plant. There are two steps involved in systematic literature reviews: formulation of the research question and systematic searching strategies consisting of identification, screening, eligibility, quality appraisal, data abstraction and analysis. The review is based on leading databases; Scopus – ScienceDirect, Springer, Taylor and Francis, and one supporting database – Google Scholar. From the review, the preferable MCA weighting model for sustainability evaluation of ethanol plants is ‘integrated Analytical Hierarchy Process (AHP)’ rather than ‘standalone AHP’. The paper offered a significant contribution to the body of knowledge and sustainability evaluation purposes.

Bioassay guided isolation was done on the Myrmecodia platytyrae (MyP) extracts in order to find the best extract that can bind with bile acid. The function of bile acid binder is to reduce the reabsorption of bile acid in the intestine so that it will cause the decrease of cholesterol in the blood circulation. The extraction process was started by using different organic solvent such as hexane, toluene, ethyl acetate, ethanol and water. All extracts were tested its bile acid binding properties and the extract gave out highest activity was selected to be fractionated. The result showed that water extract has highest bile acid binding property (75%). Then, fractionation process was performed in order to find the best fraction from water extract that have bile acid binding property. The sub-fractionation processes were continued and the process only focussed to the fraction that has highest bile acid binding property until a white powder with 97.02 % carbohydrate was obtained. The powder was subjected to FTIR and was found to have glycosidic bond as shown by bands at 1141 until 1018 cm -1 which is a character of polysaccharide. The polysaccharide rich fraction was hydrolysed and subjected to HPLC to identify its monosaccharide groups. The result showed the presence of glucose and fructose were found to be among the major monosaccharides. This result suggested that the polysaccharide from MyP water extract with high bile acid binding property was gluco-fructan.

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