p r i m a r y cardiac lymphoma; echocardiography Case Report A previously healthy 85-year-old woman pre-Address for correspondence and reprint requests: Dennis Center, 759 Chestnut Street, Springfield, MA 01199. Fax: 413-794-0198. nificant respiratory variation. The junction of was also spared. The pacing wires were free of A. Tighe, M.D., Division of Cardiology, Baystate Medical the superior vena cava with the right atrium
We present the case of an 11.5-year-old girl with M1 acute myelogenous leukemia (AML) who had isolated extramedullary relapse develop in both breasts 12 months after diagnosis and 7 months off chemotherapy. She received further chemotherapy, focal radiation therapy, then underwent a matched, unrelated bone marrow transplant and continues in remission 37 months later. Review of the literature revealed 10 cases in other children younger than 21-years-old with AML and breast involvement. These cases are summarized, and potential pathophysiologic mechanisms of spread are discussed. Breast involvement in AML is rare in children. However, regular breast examinations should be performed as part of routine follow-up in all girls with AML.
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