It is well known that periodontitis causes rapid destruction of gingival and bone tissues. Topical treatments are suitable because the drug can be delivered in a proper and controlled concentration. Metronidazole proved to be efficient for patients with aggressive periodontitis. By this study we aimed to obtain spongious drug delivery systems for local periodontitis treatment based on collagen, strontium renalate and metronidazole. Collagen spongious forms were obtained by lyophilisation of composite gels based on collagen:strontium ranelate (50:50) and different concentrations of metronidazole. The obtained spongious forms were characterized by FT-IR, water up-take, optic microscopy and in vitro release of metronidazole. The prepared matrices absorbed a maximum amount of water after 30 min. The most absorbent sample is the reference one (only collagen) which absorbed about 35% water; the adding of metronidazole decrease the water absorption due to its lipophilic behavior. The samples with strontium are more compact and they absorbed less water than the ones without strontium. Because the samples were not cross-linked they degrade during 24 hours of water absorption process. The drug percentage released was influenced by the drug and strontium ranelate concentrations. The analysis performed sponges indicate that these composites can be useful as drug delivery supports.
A lot of biomaterials were investigated as suitable scaffolds for wound healing, very high costs being involved for treating their complications and consequences. Among them, a special attention is given to collagen, a natural biopolymer which showed positive effect on soft tissue regeneration. A key factor encountered in wound healing is represented by the pain control. Thus, the purpose of this study was to design and characterize some 3D composites based on collagen and lidocaine hydrochloride as anesthetic drug model with analgesic properties. Type I fibrillar collagen gel (1.40% w/w, 3.5 pH) was extracted from calf hide by the technology currently used in Collagen Department of Division Leather and Footwear Research Institute. The collagen composites were obtained by freeze-drying of gels adjusted at 1% and 7.2 pH, with different sodium carboxymethylcellulose (NaCMC) (0; 20 and 40%) concentrations (reported to dry gel), with 0.5% and without lidocaine, un-and crosslinked with glutaraldehyde (0.5% reported to collagen dry substance). The 3D composites were evaluated through water absorption, FT-IR spectroscopy, and enzymatic degradation. The in vitro release of lidocaine from the tested formulations was performed using a sandwich device adapted to a dissolution equipment. A typical biphasic drug release profiles was recorded, with an important lidocaine burst release effect in the first minutes, ensuring a rapid pain diminution, followed by a prolonged release over next hours. The lidocaine release from the designed formulations showed an anomalous drug transport kinetic mechanism. The composites showed a porous structure, proper swelling behaviour for wound exudates and degradation in time. The collagen-NaCMC-based composites could be a promising solution in wound healing management.
Collagen is one of the most used biomaterials for bone defects repair, proving good results in tissue reconstruction research, and also its features recommend it as a very attractive drug delivery scaffold for local treatment of the affected osseous tissue. The inflammatory response is a common reaction that occurs in bone disease, the topical administration of anti-inflammatory drugs (NSAIDs) representing a reliable strategy to overcome this issue. The purpose of this paper was the physical-chemical and biopharmaceutical evaluation of some spongious matrices consisting of collagen as release support and niflumic acid as drug NSAID model, usable in bone tissue regeneration. Type I fibrillar collagen gel (2.4% w/w, 3.5 pH) was extracted from calf hide by the technology currently used in Collagen Department of Division Leather and Footwear Research Institute. The collagen sponges were obtained by freeze-drying of gels adjusted at 1% and 7.3 pH, with different dextran (0; 10 and 20%) and MgO (0; 30 and 60%) concentrations (reported to dry collagen), with 0.5% and without niflumic acid (NA) (reported to gel) and the same amount of glutaraldehyde (0.5% reported to collagen dry substance). The sponges were evaluated through water absorption, FT-IR spectroscopy and optical microscopy. In vitro NA release from the designed sponges was carried out using a sandwich device adapted to a dissolution equipment. Power law kinetic model was applied to explain drug release from the tested formulations. The NA release from collagen sponges showed a non-Fickian transport mechanism. The addition in different concentrations of dextran and MgO leads to more compact structures and improves stability of collagenic matrices. Our results showed that the designed support could be adequate for treating the inflammation associated with a bone defect in orthopedic surgery.
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