New Treatment for Dentistry Regeneration Based on Metronidazole Release from Collagen/Strontium Sponges

Abstract

It is well known that periodontitis causes rapid destruction of gingival and bone tissues. Topical treatments are suitable because the drug can be delivered in a proper and controlled concentration. Metronidazole proved to be efficient for patients with aggressive periodontitis. By this study we aimed to obtain spongious drug delivery systems for local periodontitis treatment based on collagen, strontium renalate and metronidazole. Collagen spongious forms were obtained by lyophilisation of composite gels based on collagen:strontium ranelate (50:50) and different concentrations of metronidazole. The obtained spongious forms were characterized by FT-IR, water up-take, optic microscopy and in vitro release of metronidazole. The prepared matrices absorbed a maximum amount of water after 30 min. The most absorbent sample is the reference one (only collagen) which absorbed about 35% water; the adding of metronidazole decrease the water absorption due to its lipophilic behavior. The samples with strontium are more compact and they absorbed less water than the ones without strontium. Because the samples were not cross-linked they degrade during 24 hours of water absorption process. The drug percentage released was influenced by the drug and strontium ranelate concentrations. The analysis performed sponges indicate that these composites can be useful as drug delivery supports.

Drug Delivery (Nano)Platforms for Oral and Dental Applications: Tissue Regeneration, Infection Control, and Cancer Management

“…[132] Collagen/SrRn composite gels have been experimentally investigated as drug delivery systems for treatment of localized periodontitis. [133] In an in vitro study, Sr 2+ -doped mesoporous bioactive glass was used as a drug delivery system for dental tissue engineering. The presence of Sr 2+ enhanced bone interconnectivity and sustained drug release.…”

The Effect of Crosslinking Agents on the Properties of Type II Collagen Biomaterials

“…The main characteristics such us high biocompatibility, controllable rate of biodegradation, absorbability as well as low antigenicity by the host tissue, excellent cell adhesion and proliferation properties afford this biopolymer a high potential to be used for applications in cartilage, bone and dentistry regeneration [3][4][5][6].…”