The pathology of essential tremor (ET) and underlying mechanisms of the disease are still unclear, but an increasing amount of research has been conducted on the subject. Discussions are ongoing about ET's definition as a neurodegenerative disease. Optic coherence tomography (OCT) provides a window to the brain where direct visualization of central nervous system (CNS) changes may be possible, and it can help us to develop a new point of view on ET. The goal of this study was to examine OCT parameters in ET. 40 ET patients and 40 healthy controls, i.e., a total of 160 eyes were evaluated. Retinal nerve fiber layer (RNFL), ganglion cell layer (GCL), inner plexiform layer (IPL), and choroid thinning were analyzed using spectral domain OCT. The mean age was 25.77 ± 8.98 in the ET group and 27.25 ± 8.22 in the control group. We found a decreased global RNFL thickness for both eyes in ET patients. All GCL and IPL thickness parameters were lower in the patients with ET (P < 0.001, P 0.03). Choroid was significantly thicker in ET patients than the controls (P < 0.001). Our study's results suggest that the usefulness of OCT in detecting neurodegeneration in ET. RNFL, GCL, IPL measurements are highly reproduced findings of neurodegeneration. Increased choroid volume may indicate neuroinflammation. Eyes in ET may shed light on nature of the disease, and may be used as a diagnostic tool.

The aim of our study is to assess retinal nerve fiber layer (RNFL), the ganglion cell layer (GCL), inner-plexiform layer (IPL), and choroidal layer in migraine patients with white matter lesion (WML) or without WML, using spectral domain optical coherence tomography (OCT). To our study, 77 migraine patients who are diagnosed with migraine in accordance to the International Classification of Headache Disorders (ICHD)-3 beta and 43 healthy control are included. In accordance to cranial MRI, migraine patients are divided into two groups as those who have white matter lesions (39 patients), and those who do not have a lesion (38 patients). OCT was performed for participants. The average age of participants was comparable. The RNFL average thickness parameter in the migraine group was significantly lower than in the control group (p < 0.01). However, no significant difference was detected among those migraine patients who have WML, and those who do not have. No significant difference is detected among all groups in terms of IPL, GCL, and choroidal layer measuring scales. The proofs showing that affected retinal nerve fiber layer are increased in migraine patients. However, it is not known whether this may affect other layers of retina, or whether there is a correlation between affected retinal structures and white matter lesions. In our study, we found thinner RNFL in migraine patients when we compared with controls but IPL, GCL, and choroid layer values were similar between each patient groups and controls. Also, all parameters were similar between patients with WML and without WML. Studies in this regard are required.

Karpal tünel sendromu median sinirin karpal tünel seviyesinde sıkışmasından kaynaklanan ve en yaygın görülen mononöropati şeklidir. Büyük bir kısmı idiopatik olan bu tablonun fizyopatolojik mekanizması halen tam açıklanamamıştır. Bu çalışmada karpal tünel sendromunda sistemik inflamasyonun olası rolünün nötrofil-lenfosit oranı, platelet-lenfosit oranı ve ortalama platelet hacmi değerleri ile incelenmesi amaçlanmıştır. Gereç ve Yöntem: Çalışmaya yaşları 20 ve 60 arasında değişen, elektrofizyoloji laboratuvarımıza refere edilen ve Amerikan Nöroloji Akademisi kriterlerine göre karpal tünel sendromu tanısı konulan toplam 55 hasta ve sağlıklı 36 kişi dahil edildi. Hastalar elektrofizyolojik bulgulara göre hafif, orta ve şiddetli olmak üzere üç alt gruba ayrıldı. Hastaların klinik açıdan fonksiyonel durumları ve hastalık şiddetleri Boston Questionnaire ile değerlendirildi. Bulgular: Çalışmaya dahil edilen 91 hastanın 71'i (%78,02) kadın ve 20'si (%21,98) erkekti. Hasta grubu yaş ortalaması 50,04±9,78 olan 43 kadın ve 12 erkekten oluşmaktaydı. Kontrol grubu yaş ortalaması 49,92 ±7,59 olan 28 kadın ve 8 erkekten oluşmaktaydı. Hasta ve kontrol grupları karşılaştırıldığında nötrofil-lenfosit oranı, platelet-lenfosit oranı ve ortalama platelet hacmi değerleri arasında anlamlı fark saptanmadı. Ölçülen değerler hasta alt gruplarında karşılaştırıldığında hastalık şiddetiyle değerler arasında anlamlı fark saptanmadı. Sonuç: Karpal tünel sendromu patofizyolojisinde sistemik inflamasyonun rolünün belirsiz olduğu, bazı mekanik ve lokal patolojilerin etyopatogenezi aydınlatmakta daha ön planda düşünülmesi gerektiği akla yatkın görünmektedir. Konu ile ilgili hasta sayısının artırıldığı çok merkezli ve uzunlamasına çalışmalara ihtiyaç olduğu kanaatine varıldı.

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To investigate the knowledge and awareness of physicians working in tertiary healthcare institutions concerning stroke and treatment approaches for ischemic stroke. Material and Method:Fifty-nine physicians with a mean age of 35.4 years were included in the study. A survey consisting of 12 questions taking less than 5 minutes to complete was delivered to the specialist and research assistant physicians who were actively employed in Adıyaman University Faculty of Medicine Training and Research Hospital and signed the voluntary informed consent form.Results: Of the physicians participating in the study, 66.1% (n=39) were working as specialists and 33.9% (n=20) as research assistant physicians. More than half the physicians (57.6%, n=34) had not previously attended an informative meeting on stroke. The average rate of correct answers given to all survey questions was 37.8%. The research assistant physicians correctly answered the questions concerning the first intervention in a stroke patient, prevalence of stroke, and thrombolytic treatment agent at a higher rate than the specialist physicians. The physicians who had previously attended an informative meeting on stroke provided more correct answers to the questions on stroke preventability and thrombolytic treatment agent. Conclusion:Undoubtedly, since time is one of the most important factors affecting mortality and morbidity in case of an ischemic stroke, it is vital that both society and healthcare professionals become aware of this health condition. We believe that the awareness of all physicians concerning stroke and its treatment should be increased through effective training and informative meetings.