Recurrent aphthous stomatitis (RAS)is a common oral mucosal disease in human. This disease affect 20-25% ofpopulation. The etiology remains unclear, but some of cytokine such as TNF-α is suspected to contribute in thepathogenesis of RAS. TNF-α is commonly measured by PBMC and lesional biopsy. These are invasive method andhigh skilled requirement. Another study used lesional swab to measure this cytokine without correlating the resultwith TNF-α measured by PBMC level. This study aimed to asses TNF-α level correlation between lesional swab andPBM of RAS patients. The study involved 10 subjects by inclusion criteria. Subjects have lesion swab and PBMCexamined. Samples were analyzed by ELISA method. There is a correlation between lesional swab and PBMC ofTNF-α level RAS patients but this correlation did not statistically significant.
Background: Candida albicans are normal flora in the oral cavity and can turn into pathogens. Antifungal drugs need to be given to inhibit the growth of the fungus; using traditional medicine, for example moringa seeds. Moringa seeds contain natural compounds like polyphenols and flavonoids as an antifungal.Objective: To determine the inhibition of Moringa oleifera L. seed extract on the growth of C.albicans. Method: This experimental laboratory research was designed with posttest only control group with agar/Kirby Bauer diffusion method, carried out with 4 repetitions by treated extract with 40%, 60%, 80%, 100% concentration, positive control (ketoconazole) and negative controls (distilled water). Results: Krusskal Wallis test showed p value = 0.000 (p <0.05),means Moringa seed extract with concentrations 40%, 60%, 80%, 100% had a significant effect on inhibiting the growth of C.albicans. Conclusion: Moringa seed extract can inhibit the growth of Candida albicans.
Objective: to assess awareness of senior community in the Belawa distric, Wajo, South Sulawesi, Indonesia regarding their oral soft tissue abnormality specifically regard to Oral potentially malignant disorders, and to assess community ability to descript any pain or uncomfortably origin from their oral cavity.
Methods: A self-made questionnaire written in Indonesia language was given to the old aged-adult based on WHO criteria with age range between 45 to 75 years old, who was willing to participate in this study. The questioner consists some picture representing oral mucosal cavity with clinical feature of some ulcers, clinical feature of candida infection, and some clinical appearances of oral potentially malignant disorders.
Results: In term of oral mucosal diseases questions, 22 (55%) participants had history of ulceration, however only 5 (45%) participants could specifically point out its previous ulcer location. However, history of pain only stated by 11 (28%) participants, 24 (60%) did not experienced any pain, and 5 (12%) did not answer the questions.
Conclusion: knowledge and awareness regarding oral health lesion, especially the associated-potentially malignant lesion was far from ideal in the Belawa Community.
Plants are often used as herbal medicines because their active substances have known. Mangrove as herbal medicines are still under-researched; mangrove leafextract can be useful as anti-inflammatory, antibiotic, hemolytic drug, hypoglycemic has been specifically investigated for its inhibitory power againstStaphylococcus aureus as one of the causes of angular cheilitis and shows good results. This true experimental laboratory research with a posttest only control group design used 24 male white rats of the Wistar strain which were divided into group-1 were induced with S.aureus and given mangrove leaf extract, thegroup-2 was induced with S.aureus and given gentamicin, the group-3 was induced with C.albicans and given mangrove leaf extract, and the group-4 was induced with C.albicans and given miconazole. On the third day, wound length in the first group-1 was 0.23±0.2, in the group-2 was 0.00±0.0, in the group-3was 0.21±0.2, and the group-4 was 0.16±0.2. Based on the Friedman test, it showed significant results (p<0.05). It was concluded that mangrove leaf extract accelerated the wound closure process of angular cheilitis induced by S.aureus and C.albicans.
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