A simple, sensitive, precise, specific, rapid, accurate, and novel reverse phase high performance liquid chromatography (RP- HPLC) method for determining carvedilol (CAR) and ivabradine (IVA) in bulk and its formulation has been developed validated.

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By unusual method for separating two isomers of a substituted nitro-coumarin using a soxhlet extractor and in controlling temperature to get a selective nitration reaction, several new Schiff base coumarins were synthesized from nitro coumarins as starting material, which were reduced by Fe in glacial acetic acid to produce corresponding amino coumarin derivatives. Then the latter was reacted with different aromatic aldehydes to produce the desired Schiff bases derivatives. After characterization by Fourier transform infrared (FT-IR), Proton nuclear magnetic resonance (1HNMR) and Carbon-13 nuclear magnetic resonance (C-NMR), all these compounds were evaluated as potential Antimicrobial and Antioxidant Agents.

For managing the digestive tract and immune system, probiotic has been recommended more frequently as an effective therapy and are known as the agent of cholesterol-lowering. The definition of hypercholesterolemia is, increase of plasma cholesterol levels excessively above 200 mg/dL, the patients may have a strong risk to cardiovascular disease. The aims of this study is used different types of probiotic sources of treating patients with hypercholesterolemia with no cardiovascular disease for 30 days. The results show that, there are significant differences (p < 0.05) between cholesterol, Low-density lipoprotein (LDL) and High-density lipoprotein (HDL) before and after the consumption of probiotics from different sources, while triglyceride and glucose show there are no significant differences after 30 days (p > 0.05).

Intramolecular radical cyclization of the unsaturated cyano amides (VI) and (XIV) yields the N‐cyanooctahydroindoles (VII) or (XV).

Aus den Cycloalkenolen (I) und dem Phenylselenobutyrylchlorid (II) erhält man die Carbonsäureester (III), die über eine Umlagerung zu den Cycloalkenyl‐substituierten Silylestern (IV) führen.

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