Stability Indicating Method Development and Validation of Carvedilol and Ivabradine in Bulk and its Formulation by Reverse Phase High Performance Liquid Chromatography Method

Mohammed, Ali Y.

doi:10.25258/ijddt.12.3.70

Cited by 2 publications

(2 citation statements)

References 11 publications

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“…Recovery rates for both medicines came close to 100%, and the values of % RSD were well within the allowed range of 2%. Examining pharmaceutical formulations shows that the suggested method can simultaneously determine these components with minimal interference from other additives (Chavan et al 2022).…”

Section: Discussionmentioning

confidence: 98%

Development and validation of ultraviolet spectrophotometric method for Saquinavir estimation in bulk and dosage form

Mujawar

Ahmad

Tajane

et al. 2023

Multidiscip. Sci. J.

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We developed and validated a simple, rapid, sensitive, precise, and reproducible specific UV spectrophotometric technique for determining Saquinavir in bulk medication and pharmaceutical dosage form. Methods: As per ICH recommendations, a simple double-beam UV spectrophotometric technique has been designed and validated with several criteria, such as linearity, precision, repeatability, the limit of detection (LOD), limit of quantification (LOQ), and accuracy. Results: UV-visible spectrophotometric approach, measurement of absorption at the maximum wavelength in 10 mL methanol, and volume made with water solvent system as reference Saquinavir was discovered at 239 nm. The medicine followed Beer's rule and showed a good correlation. Beer's law was followed for Saquinavir in the 1-5µg/ml concentration range, with a correlation coefficient of 0.999. Saquinavir's LOD and LOQ were determined to be 0.56 μg/ml and 2.78 μg/ml, respectively. The proposed method is simple, precise, accurate, and reproducible, and it may be utilized for routine analysis of Saquinavir in bulk and tablet dosage form.

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Section: Discussionmentioning

confidence: 98%

Development and validation of ultraviolet spectrophotometric method for Saquinavir estimation in bulk and dosage form

Mujawar

Ahmad

Tajane

et al. 2023

Multidiscip. Sci. J.

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“…Note: Caspofungin acetate storage condition at -70 ± 10℃. For the thawing process, caspofungin acetate solid samples during routine testing can be transferred from a -70℃ freezer to a 2 to 8℃ refrigerator to thaw for about 20 minutes and then transferred to room temperature to stand for 1-hour Validation [13][14][15][16][17] System suitability "Six separate injections were made into the chromatograph for the system suitability solution, diluent, sensitivity solution, and standard solution replicates. The resulting chromatograms were recorded.…”

Section: Reference Solutionmentioning

confidence: 99%

Method Development and Validation of Indigenously Isolated Caspofungin Acetate and its related Substances using RP-HPLC Method

Gannamani,

Chintakula,

Maddila

2023

IJPQA

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Caspofungin is prepared from a precursor PneumocandinB0 derived from a fungus Glarea lozoyensis. Prepared crude caspofungin acetate has many impurities, namely, A, B, D, E and PneumocandinB0, and these impurities vary slightly in chemical or structural composition and need to be eliminated by purification. The present study involves the preparation of caspofungin acetate from PneumocandinB0, followed by purification and method development for detecting caspofungin and its related substances.”We used a high-tech liquid chromatograph system, which included components like the Agilent 1260 infinity quaternary pump module, a sophisticated MWD detector, and the Empower 3 data handling system. To separate and analyze substances, we employed an analytical column made of stainless steel. This column was 150 mm long and had an internal diameter of 3.0 mm. It was filled with octadecyl silane chemically bonded to porous silica particles, each with a tiny diameter of 3 micrometers. The test method underwent validation to ensure it could accurately identify specific elements, detect minimal quantities, establish the lowest measurable amounts, maintain linearity, demonstrate precision, achieve accuracy, and suitably handle sample solutions and the system.” and the developed test method is suitable and can be introduced into the routine use for the detection of caspofungin acetate and its related substances.

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Stability Indicating Method Development and Validation of Carvedilol and Ivabradine in Bulk and its Formulation by Reverse Phase High Performance Liquid Chromatography Method

Abstract: A simple, sensitive, precise, specific, rapid, accurate, and novel reverse phase high performance liquid chromatography (RP- HPLC) method for determining carvedilol (CAR) and ivabradine (IVA) in bulk and its formulation has been developed validated.

Cited by 2 publications

References 11 publications

Development and validation of ultraviolet spectrophotometric method for Saquinavir estimation in bulk and dosage form

Development and validation of ultraviolet spectrophotometric method for Saquinavir estimation in bulk and dosage form

Method Development and Validation of Indigenously Isolated Caspofungin Acetate and its related Substances using RP-HPLC Method

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