There are no published cases about bullous pyoderma gangrenosum induced by leucovorin, fluorouracil and oxaliplatin (FOLFOX) chemotherapy. With the increasing incidence of gastric and colorectal cancers and the increased usage of targeted therapies, some cutaneous adverse effects may become common. An 84-year-old male presented to our clinic with multiple ulcerative plaques covered with hemorrhagic crusts on both extremities after several FOLFOX chemotherapy sessions for gastric cancer and liver metastasis. Two weeks later, multiple bullae also appeared, especially on the acral areas. The histopathology examination was compatible with acute leukocytoclastic vasculitis. The FOLFOX chemotherapy regimen is increasingly administered considering the rising incidence of gastrointestinal cancers. Hence, our understanding of its possible side effects and complications must be heightened. Anti-
A 34-year-old female patient presented with recurrent bilateral hypopigmented macules on the labia majora. The lesions were treated with topical steroids, which led to mild improvement, but erosive plaques developed after discontinuing the treatment. Histopathological findings were compatible with extramammary Paget disease (EMPD), which was treated with radical vulvectomy with no recurrence in the next months of follow-up.
Dear Editor, COVID-19 pandemic had spread rapidly all around the world leading to variety of manifestations that ranged from being asymptomatic to death. 1 While COVID-19 vaccination has played a very important role in ending this pandemic, adverse reactions are increasingly reported including cutaneous ones. Injection-site local reactions are among the most common reported cutaneous manifestations, followed by urticaria, pityriasis rosea-like lesions, and pernio/chilblains. 2 Herein we report a post-vaccine urticarial eruption that had unique presentation and could be considered a new urticarial variation following COVID-19 vaccination.Herein, we report a 58-year-old woman with no significant past medical history presented to our clinic with 1 week history of pruritic lesions on trunk and both lower extremities. The eruption had
Leukemia cutis is a cutaneous manifestation of leukemia. Herein, we
present a rare cutaneous manifestation of leukemia cutis in a patient
with myeloid leukemia m5, characterized by hyperpigmented red-to-brown
patches on face and upper trunk. To our knowledge, hyperpigmented
patches secondary to leukemia cutis is rarely described in the
literature.
Colorectal cancer is a fatal disease that is steadily increasing.
Herein, we report a 36-year-old male with a seven-month history of colon
adenocarcinoma, who presented with a painless, exophytic, bilateral
scrotal mass, mimicking lymphangioma in shape. To our knowledge,
cutaneous metastasis mimicking lymphangioma is rarely described in the
literature.
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