Figurate purpuric eruption post‐COVID‐19 vaccination

Abstract

Dear Editor, COVID-19 pandemic had spread rapidly all around the world leading to variety of manifestations that ranged from being asymptomatic to death. 1 While COVID-19 vaccination has played a very important role in ending this pandemic, adverse reactions are increasingly reported including cutaneous ones. Injection-site local reactions are among the most common reported cutaneous manifestations, followed by urticaria, pityriasis rosea-like lesions, and pernio/chilblains. 2 Herein we report a post-vaccine urticarial eruption that had unique presentation and could be considered a new urticarial variation following COVID-19 vaccination.Herein, we report a 58-year-old woman with no significant past medical history presented to our clinic with 1 week history of pruritic lesions on trunk and both lower extremities. The eruption had

A Systematic Review of Histopathologic Surveys on Mucocutaneous Biopsies in Patients Developed COVID-19 Vaccine-Related Dermatologic Manifestations

“…In multiple studies, histopathologic evaluation of vasculitis lesions showed leukocyte infiltration into the endothelia resulting in inflammation and swelling. [9][10][11][12][13][14][15][16][17][18][19] Subsequently, perivascular mixed lymphocytes, neutrophils, and occasional eosinophils plus marked debris and red blood cells (RBCs) extravasations were reported, which was consistent with leukocytoclastic vasculitis 10,11,13,14,16,[18][19][20][21][22][23][24][25][26][27] ; these findings were also observed in 2 other cases: a figurate purpuric eruption 28 and a pigmented purpuric dermatosis. 29 Furthermore, immunofluorescence microscopy was performed on some samples, and deposition of C3, fibrin, fibrinogen, immunoglobulin M, and IgA were reported.…”

Prevalence, Pathophysiology, and Treatment of Urticaria post-COVID-19 Vaccination: A Systematic Review

“…Either IgE mediated or IgG is the reaction from hypersensitivity after vaccine administration. It is caused by complement-mediated anaphylactic and delayed T-cell-mediated reactions IgE (Namazi et al, 2022).…”

“…Morbilliform eruptions and urticaria are the main reason for hypersensitivity reactions primarily (Namazi et al, 2022). Three of four patients developed recurrent delayed urticaria after the second dose of the COVID-19 vaccine.…”

“…Either IgE mediated or IgG is the reaction from hypersensitivity after vaccine administration. It is caused by complementmediated anaphylactic and delayed T-cell-mediated reactions IgE (Namazi et al, 2022) c. Urticaria treatment post-COVID-19 vaccination Second-generation H1 antihistamine is the first-line treatment that resulted in half of reduction in the urticaria treatment. Treatment of omalizumab is required to prevent urticaria flares during the vaccination period (Grieco et al, 2022).…”