Objective: Acute inflammation of the appendix is a very common finding in patients representing the emergency department. Here, we assessed the levels of the serum laboratory biomarkers in the patients with complicated (defined by the presence of perforation, abscess, or peritonitis) and simple appendicitis. Methodology: This observational study was conducted in Sina Hospital, Tabriz-Iran, between March 2019 and August 2019. Data regarding age, sex, body temperature, length of hospital stays, clinical signs and symptoms, and time of symptom onset for each patient. Laboratory values including white blood cells (WBC) count, neutrophil percentage, erythrocyte sedimentation rate (ESR), C-reactive protein (CRO), mean platelet volume (MPV), and lactate dehydrogenase (LDH) were evaluated. Results: A total of 279 patients were enrolled in the study. 131 patients (46.9%) had complicated and 148 (53.0%) had simple appendicitis. Mean body temperature (P-value <0.05) and CRP levels (P-value <0.0001), were significantly higher in the complicated appendicitis group. (P-value >0.05). There were no significant differences regarding WBC, neutrophil, 1 st and 2 nd hour ESR, MPV, and LDH levels, and mean length of hospital stay (P-value>0.05). Conclusion: CRP concentrations are reliable markers showing an increased risk of developing complications in acute appendicitis patients.
Background: APACHE Score is an important criterion for determining the patient prognosis, especially in critically ill patients. According to significantly changes in the serum levels of thyroidal hormones in patients, especially in critically ill patients, the aim of the present study was to evaluate the relationship between thyroid function and APACHE 4 score in the prognosis of the traumatic patients admitted in surgery ICU. Method & Material: In a descriptive-analytical study, 90 patients with multiple trauma were studied. Thyroid hormones and APACHE 4 Score were evaluated on 1st, 5th and10th days of admission for each patient. Their clinical features and duration of hospitalization, either in trauma unit or ICU, elation between thyroidal hormones and APACHE 4 Score, duration of hospitalization, and survival of patients were evaluated. Results: This study included 90 patients. A statistically significant relation was detected between thyroid hormones (TT3) and APACHE 4 Score and duration of hospitalization. Conclusion: TT3 might be utilized as a prognostic factor in the traumatic patients admitted to ICU.
Background: gastric cancer (GC) is one of the common cancers with a high mortality rate and complex pathogenesis. In recent years many studies focused on the roles of non-coding RNA in GC biology. Long noncoding RNAs (lnc-RNAs) like HOTAIR and SNHG-7 are a class of non-coding RNA that can affect the cell’s biology by sponging of micro-RNAs. Recent studies reveal the relation between these lnc-RNAs and miR-34a expression which can affect various molecular pathways in malignant cells. Methods: GeneAll Trizol RNA extraction kit (Korea) was used to extract total RNA according to the supplied procedures and gene expression was evaluated. The qRT-PCR assay was performed to evaluate the expression levels of miR-34a, HOTAIR, and SNHG-7 in GC and paired marginal tissue specimens. The AUC of the ROC curve was estimated based on their expression in GC and gastric normal tissues to evaluate their diagnostic accuracy.Results: Expression levels of miR-34a were higher in adjacent marginal samples compared to GC tissue samples. We noted significantly higher levels of HOTAIR expression in GC samples compared to non-tumor adjacent tissue samples and the expression of HOTAIR in GC tissues was negatively correlated with mir-34a. Similarly, we noted GC tissue samples showed higher levels of SNHG-7 expression and that SNHG-7 expression was negatively correlated with mir-34a. Regarding the clinicopathological factors, miR-34a expression was lower in patients with advanced GC, while enhanced expression of HOTAIR and SNHG-7 was noted in these patients. Conclusion: Our findings suggested that miR-34a, HOTAIR, and SNHG-7 expression levels have high potential as diagnostic markers for discriminating GC patients from normal cases. In Addition, there is a negative correlation between miR-34a with two other genes which suggests the regulatory effects of HOTAIR and SNHG-7 on miR-34a.
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