Objective:The aim of this study is to assess the accuracy of radiologic findings of renal masses by comparing them with the histopathologic diagnoses from our personal experience in partial nephrectomy specimens.
Methods:We reviewed the histopathological reports of 49 patients who underwent partial nephrectomy in a 10 year duration at Prince Hussein bin Abdullah urology and organ transplant centre Results: Only 32 patients of 49 harbored renal cell carcinoma in their specimens with a percentage of 65.4%. The remaining 15 patients had benign renal conditions in a percentage of 30.6%Conclusion: Partial nephrectomy is gold standard for small renal masses, which lead to preserve renal tissue and decrease morbidity and mortality from chronic kidney disease knowing that not all masses proved to be renal cell carcinoma. Despite the fact that renal CT-Scan with IV contrast is considered as the modality of choice for the diagnosis of renal tumors still there is a false positive rate although low but exist.
Background
Alkaptonuria is a rare genetic metabolic disorder due to deficiency of homogentisate 1,2-dioxygenase (HGD), an enzyme catalyzing the conversion of homogentisate to 4-maleylacetoacetate in the pathway for the catabolism of phenylalanine and tyrosine. HGD deficiency results in accumulation of homogentisic acid and its pigmented polymer. Ochronosis is a bluish-black discoloration due to the deposition of the polymer in collagenous tissues. Extensive ochronotic involvement of the Achilles tendon in alkaptonuria and its surgical treatment is rarely reported.
Case report
A 43-year-old man presented to our clinic in March 2019 with sudden onset of left Achilles tendon pain with no history of prior trauma. Surgical exploration revealed a complete disruption of the tendon at its attachment to the calcaneus. Black pigmentation was extensive and reached the calcaneal tuberosity, extending about 7 cm from the insertion.
Discussion
Achilles reconstruction was performed using flexor hallucis longus tendon transfer. The patient experienced uncomplicated healing with satisfactory functional results.
Conclusion
Orthopedic surgeons should be aware of the progressive nature of alkaptonuria. Extensive degenerative changes of the ruptured tendon should be suspected so that physicians can plan tendon repair and facilitate prompt surgical intervention.
Introduction: PSA is considered as a tumor marker for prostate cancer which has helped since its first application in the early detection, prognosis and follow up of patients with prostate cancer. In our study we collect the results of bone scans of patients with prostate cancer and correlate them with their serum PSA value to predict the efficacy of PSA value in predicting bone metastases. Material and methods: Our study was in 102 patients with prostate adenocarcinoma who were treated in our urology center and sent for staging in the nuclear medicine Lab for bone isotope scan for the detection of bone metastases in addition to the collection of their PSA value and the comparison between scan results and PSA value. Results: We divided our patients into two groups according to their PSA value considering the first one with patients of PSA more than 20ng/ml and the second group with PSA of less than or equal to 20ng/ml. The results were 82.7% of patients with PSA more than 20ng/ml to have a positive scan with bone metastases and 82% of patients with PSA less than or equal to 20ng/ml to have a negative scan. Conclusion: PSA can be considered as a good tool for the prediction of bone metastases in patients with prostate cancer especially for patients with a PSA value of 20 ng/ml and more, and as an accepted tool when the PSA value is 10-20 ng/ml.
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