The study examined the efficacy of rational emotive behaviour therapy on depression among secondary school going adolescents in Yobe Islamic Centre Damaturu, Yobe State, Nigeria. Quasi-experimental research design was used in the study. Purposive sampling technique was used to select 30 students for the study. The sample participants consist of 15 male and 15 female students. Beck's Depression Inventory (BDI) was administered to assess depression before and after the intervention with .85 reliability co-efficient. REBT was employed as the treatment to the experimental group. T-test statistical tool was used to test the 3 hypotheses formulated. The result revealed that REBT was significantly effective on the management of depression; difference in the management of depression was significant to Gender but not for age. In view of these findings, the study recommended that students should be trained on the effective usage of this intervention (REBT), Experts in educational Counseling/Educational psychologists should intensify their effort to organize seminars/conferences on the implications of this intervention.