Background: JARID1B is an H3K4 histone demethylase and an attractive target for cancer therapy.Results: High throughput screen identified novel compounds that can inhibit JARID1B demethylase activity. Conclusion: Drug-like small molecules can be identified to inhibit JARID1B. Significance: The identified JARID1B inhibitors are lead compounds that can be developed into anti-cancer epigenetic drugs.
This article summarizes what we know about marketplaces in the United States, relates that knowledge to a research agenda on the subject, and makes suggestions for planning practice. This review accomplishes these three goals beginning with a historical review of marketplaces, focused mostly on the United States. The research literature on marketplaces is reviewed from political, economic, social, and health perspectives with suggestions for further basic and applied research. In short, the article shows how marketplaces were once tools of nascent planning and public policy, describes the reasons they should be again, and shows how planners and policy makers can advance public purposes through markets.
Public markets were once essential parts of the cityscape and they are becoming so again. Markets serve several purposes, social, political, and economic, and so planners interested in multipurpose tools for development will be interested in public markets. Markets can help achieve a variety of goals including place-making, employment, and entrepreneurship. This article focuses on markets as tools of business incubation. Archival data and literature shows how important markets once were to cities. Ethnographically collected data from Chicago's Maxwell Street market illustrates the individual and structural factors that account for businesses created at the market. Rural and urban markets are emerging or being rehabilitated all over the country — this research helps planners understand the history of markets, their multi-disciplinary nature, and the circumstances of people creating businesses at markets.
Summary. We have retrospectively analysed 344 multiple myeloma (MM) patients (202 de novo patients) treated in a non-uniform way in whom high-dose therapy and autologous stem cell transplantation (ASCT) response was simultaneously measured by both electrophoresis (EP) and immunofixation (IF). Patients in complete remission (CR) by EP were further subclassified as CR1 when IF was negative and CR2 when it remained positive. Partial responders (PR) were also subclassified as PR1 (very good PR, . 90% reduction in M-component) or PR2 (50±90% reduction). CR1 patients showed a significantly better event-free survival (EFS) [35% at 5 years, 95% confidence interval (CI) 17±53, median 46 months] and overall survival (OS) (72% at 5 years, CI 57±86, median not reached) compared with any other response group (univariate comparison P , 0´00000 to P 0´004). In contrast, comparison of CR2 with PR1 and with PR2 did not define different prognostic subgroups (median EFS 30, 30 and 26 months respectively, P 0´6; median survival 56, 44 and 42 months respectively, P 0´5). The non-responding patients had the worst outcome (5-year OS 8%, median 7 months). Multivariate analysis confirmed both the absence of differences among CR2, PR1 and PR2 and the highly discriminatory prognostic capacity of a threecategory classification: (i) CR1 (ii) CR2 1 PR1 1 PR2, and (iii) non-response (EFS P , 0´00000; OS P , 0´00000; both Cox models P , 0´00000). In the logistic regression analysis, the factors significantly associated with failure to achieve CR1 were the use of two or more up-front chemotherapy lines, status of non-response pre-ASCT and inclusion of total body irradiation (TBI) in the preparative regimen. Tandem transplants or the use of multiple agents (busulphan and melphalan) in the preparative regimen resulted in a higher CR1 level; none of the biological factors explored influenced the possibility of achieving CR1. These results confirm that, in MM patients undergoing ASCT, achieving a negative IF identifies the patient subset with the best prognosis; accordingly, therapeutic strategies should be specifically designed to achieve negative IF.
The automatic method described is effective in terms of CD34+ cell recovery and viability in ASCT. Moreover, Sepax decreased significantly the untoward reactions during the infusion.
Women who selected to be interviewed in Spanish were less likely to report age-appropriate cancer examinations, health insurance and a regular health care provider than those who selected to be interviewed in English. Disparities in cancer screenings among vulnerable Hispanic populations could be reduced by promoting the establishment of a regular health care provider.
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