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Grade III coronary perforation is associated with complex lesions and high acute and long-term major adverse cardiac event rates.

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In a limited and selected study population, our study showed that QFR computation may be a safe and reliable tool to guide coronary revascularization of NCLs in ST-segment-elevation myocardial infarction patients.

Using crossover balloon inflation as an adjunct to Prostar closure may be helpful for managing TAVI vascular access sites.

AimsTo assess long-term prognosis in patients with functional mitral regurgitation (FMR) and left ventricular (LV) dysfunction, receiving current standard pharmacological therapy. Methods and resultsWe prospectively enrolled 404 consecutive patients (mean age 70.2 + 10 years) with ischaemic (76.5%) and nonischaemic (23.5%) LV dysfunction (ejection fraction 34.4 + 10.8%) and at least mild MR. Results are reported at 4 years' follow-up. Survival free of all-cause mortality was 53% and cardiac death was 74%. Survival free of allcause mortality was 50% (95% CI 35 -72) for patients with moderate MR, 49% (95% CI 27-65) for severe MR, and 64% (95% CI 47-78) for mild MR (P ¼ 0.03). Survival free of cardiac death was 57% (95% CI 38-74) for patients with moderate MR, 55% (95% CI 30-77) for severe MR, and 94% (95% CI 59 -98) for mild MR (P ¼ 0.003). Moderate-to-severe MR [relative risk (RR) 2.7, 95% CI 1.2 -6.1, P ¼ 0.003] was an independent predictor of cardiac death but not of all-cause mortality. Survival free of heart failure (HF) was 32%. Survival free of HF was 20% (95% CI 17-35) for patients with moderate MR, 18% (95% CI 15-32) for severe MR, and 62% (95% CI 45 -72) for mild MR (P ¼ 0.0001). Moderate-to-severe MR (RR 3.2, 95% CI 1.9 -5.2, P ¼ 0.0001) was an independent predictor of HF. ConclusionThe mortality and morbidity of patients with LV dysfunction and FMR remain high despite current standard pharmacological therapy. Moderate-to-severe MR is an independent predictor of cardiac death and HF.--

At 5-year clinical follow-up, there was still no difference in the occurrence of major adverse cardiac and cerebrovascular events between elective PCI with DES implantation and CABG in unprotected left main coronary artery lesions in this single-center experience. There was an advantage of PCI in the composite end point of death, MI, and/or stroke, whereas a benefit in the need for reintervention was still found in CABG.