The problem of treating intra-abdominal bleeding in abdominal trauma is one of the most serious in urgent surgery. The most common cause of these hemorrhages is liver damage. For surgical hemostasis, local hemostatics and granular sorbents are becoming increasingly common. The aim of the study was to study in vivo the hemostatic properties and morphological features of the reparative regeneration of simulated bleeding liver wounds during treatment with the hemostatic agent Surgitamp and the sorbent Molselect G-50. The experiments were performed on 30 laboratory animals Chinchilla rabbits. After reproducing the model of a bleeding liver wound, bleeding was stopped in the experimental group (n = 15) by applying Molselect G-50 (4.0 g) powdered sorbent into the wound, followed by tamponing with Surgitamp hemostatic gauze (4.0 x 2.0 cm). Hemostasis in the control liver wound was carried out by applying a U-shaped suture with a PGA-3.0 thread until the edges of the wound converged. Morphological studies were performed on the 7th, 14th and 28th days of the experiment. Experimental studies have shown that the time to stop bleeding in the experimental group was 280.0 (264.0308.0) sec, in the control, the time of hemostasis was later 461.0 (420.0501.0) sec. Morphological studies have allowed us to establish differences in both the rate and quality of reparative regeneration of experimental simulated liver wounds compared with the control. Experimental studies using Molselect G-50 in combination with Surgistamp for local hemostasis of bleeding liver wounds in rabbits allowed us to conclude that such a combination makes it possible not only to reliably stop bleeding, but also promotes the stimulation of reparative regeneration.
The aim of the study was to investigate the potential of Surgitamp hemostatic gauze and Molselect G-50 sorbent application in surgical hemostasis of simulated bleeding liver wounds in an in vivo experiment on laboratory animals. Materials and methods. The study included 30 laboratory animals: Chinchilla rabbits. Laboratory animals underwent median laparotomy under intravenous anesthesia (Zoletil 100 0.1 ml /kg, Xylavet 0.1 ml/kg), the right lobe of the liver was involved into the wound. At a 20 cm distance from the surface of the liver, a metal 92 g load in the form of a triangular prism was attached to the slider with the help of a thread. By operational readiness, the thread was burned, the prism fell vertically and hit the surface of the liver with a pointed end, this resulting in a simulated bleeding liver wound: a wound of the right lobe of the liver, linear in shape 3.0x0.7 cm, 0.6 cm deep, with uneven edges and active bleeding from the defect area. Hemostasis in the experimental group of animals (n=15) was carried out by covering the wound surface with a granular sorbent Molselect G-50, followed by tamponing the wound with a strip of hemostatic gauze Surgitamp. In the control group of animals (n=15) hemostasis was carried out by stitching a bleeding liver wound with a U-shaped suture with a PHA 3.0 thread until the edges of the wound converged. The effectiveness of hemostasis of the liver wounds was evaluated using the following parameters: the time of the final bleeding arrest, the volume of blood loss, the number of episodes of repeated bleeding. Results. Experimental studies have demonstrated that the surgical hemostasis technique with the hemostatic agent Surgitamp application combined with the granular sorbent Molselect G-50 allows for reliable hemostasis of simulated bleeding liver wounds, reducing the time of bleeding arrest from 461.0(420.0-501.0) sec to 280.0(264.0-308.0) sec (P=0.0001), simultaneously reducing the incidence of recurrent hemorrhages from 46.7% to 6.7% (P=0.035).
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