Morphological assessment of reparative regeneration of experimental bleeding liver wounds in the treatment of hemostatic agent Surgitamp and granular sorbent Molselect G-50

Abstract

The problem of treating intra-abdominal bleeding in abdominal trauma is one of the most serious in urgent surgery. The most common cause of these hemorrhages is liver damage. For surgical hemostasis, local hemostatics and granular sorbents are becoming increasingly common. The aim of the study was to study in vivo the hemostatic properties and morphological features of the reparative regeneration of simulated bleeding liver wounds during treatment with the hemostatic agent Surgitamp and the sorbent Molselect G-50. The experiments were performed on 30 laboratory animals Chinchilla rabbits. After reproducing the model of a bleeding liver wound, bleeding was stopped in the experimental group (n = 15) by applying Molselect G-50 (4.0 g) powdered sorbent into the wound, followed by tamponing with Surgitamp hemostatic gauze (4.0 x 2.0 cm). Hemostasis in the control liver wound was carried out by applying a U-shaped suture with a PGA-3.0 thread until the edges of the wound converged. Morphological studies were performed on the 7th, 14th and 28th days of the experiment. Experimental studies have shown that the time to stop bleeding in the experimental group was 280.0 (264.0308.0) sec, in the control, the time of hemostasis was later 461.0 (420.0501.0) sec. Morphological studies have allowed us to establish differences in both the rate and quality of reparative regeneration of experimental simulated liver wounds compared with the control. Experimental studies using Molselect G-50 in combination with Surgistamp for local hemostasis of bleeding liver wounds in rabbits allowed us to conclude that such a combination makes it possible not only to reliably stop bleeding, but also promotes the stimulation of reparative regeneration.