IntroductionSevere asthma is a rare disease in children, for which three biologicals –anti-IgE, anti-IL-5 and anti-IL-4RA antibodies– are available in European countries. While global guidelines exist on who should receive biologicals, knowledge is lacking on how those guidelines are implemented in real life and which unmet needs exist in the field. In this survey, we aimed to investigate the status quo and identify open questions in biological therapy of childhood asthma across Europe.MethodsStructured interviews regarding experience with biologicals, regulations on access to the different treatment options, drug selection, therapy success and discontinuation of therapy were performed. Content analysis was used to analyse data.ResultsWe interviewed 37 experts from 25 European countries and Turkey and found a considerable range in the number of children treated with biologicals per centre. All participating countries provide public access to at least one biological. Most countries allow different medical disciplines to prescribe biologicals to children with asthma and only a few restrict therapy to specialised centres. We observed significant variation in the timepoint when treatment success is assessed, in therapy duration, and in the success rate of discontinuation. Most participating centres intend to apply a personalised medicine approach in the future to match patients a priori to available biologicals.ConclusionSubstantial differences exist in the management of childhood severe asthma across Europe and the need for further studies on biomarkers supporting selection of biologicals, on criteria to assess therapy response and on how/when to end therapy in stable patients is evident.
The aim of this study was to analyse the relation between professional aluminum exposure and depression. The study was performed on a number of 99 subjects exposed to aluminum, during a professional activity of 8 to 38 years in the aluminum production industry. The control group was represented by 36 subjects from the administrative sector. Chronically exposure to aluminum determined: headache, insomnia, apathy, asthenia, and a decrease in libido. Moreover, depression was more frequent in subjects chronically exposed to aluminum.
Table of contentsWORKSHOP 4: Challenging clinical scenarios (CS01–CS06)CS01 Bullous lesions in two children: solitary mastocytomaS. Tolga Yavuz, Ozan Koc, Ali Gungor, Faysal GokCS02 Multi-System Allergy (MSA) of cystic fibrosis: our institutional experienceJessica Hawley, Christopher O’Brien, Matthew Thomas, Malcolm Brodlie, Louise MichaelisCS03 Cold urticaria in pediatric age: an invisible cause for severe reactionsInês Mota, Ângela Gaspar, Susana Piedade, Graça Sampaio, José Geraldo Dias, Miguel Paiva, Mário Morais-AlmeidaCS04 Angioedema with C1 inhibitor deficiency in a girl: a challenge diagnosisCristina Madureira, Tânia Lopes, Susana Lopes, Filipa Almeida, Alexandra Sequeira, Fernanda Carvalho, José OliveiraCS05 A child with unusual multiple organ allergy disease: what is the primer?Fabienne Gay-CrosierCS06 A case of uncontrolled asthma in a 6-year-old patientIoana-Valentina Nenciu, Andreia Florina Nita, Alexandru Ulmeanu, Dumitru Oraseanu, Carmen ZapucioiuORAL ABSTRACT SESSION 1: Food allergy (OP01–OP06)OP01 Food protein-induced enterocolitis syndrome: oral food challenge outcomes for tolerance evaluation in a Pediatric HospitalAdrianna Machinena, Olga Domínguez Sánchez, Montserrat Alvaro Lozano, Rosa Jimenez Feijoo, Jaime Lozano Blasco, Mònica Piquer Gibert, Mª Teresa Giner Muñoz, Marcia Dias da Costa, Ana Maria Plaza MartínOP02 Characteristics of infants with food protein-induced enterocolitis syndrome and allergic proctocolitisEbru Arik Yilmaz, Özlem Cavkaytar, Betul Buyuktiryaki, Ozge Soyer, Cansin SackesenOP03 The clinical and immunological outcomes after consumption of baked egg by 1–5 year old egg allergic children: results of a randomised controlled trialMerrynNetting, Adaweyah El-Merhibi, Michael Gold, PatrickQuinn, IrmeliPenttila, Maria MakridesOP04 Oral immunotherapy for treatment of egg allergy using low allergenic, hydrolysed eggStavroula Giavi, Antonella Muraro, Roger Lauener, Annick Mercenier, Eugen Bersuch, Isabella M. Montagner, Maria Passioti, Nicolò Celegato, Selina Summermatter, Sophie Nutten, Tristan Bourdeau, Yvonne M. Vissers, Nikolaos G. PapadopoulosOP05 Chemical modification of a peanut extract results in an increased safety profile while maintaining efficacyHanneke van der Kleij, Hans Warmenhoven, Ronald van Ree, Raymond Pieters, Dirk Jan Opstelten, Hans van Schijndel, Joost SmitOP06 Administration of the yellow fever vaccine in egg allergic childrenRoisin Fitzsimons, Victoria Timms, George Du ToitORAL ABSTRACT SESSION 2: Asthma (OP07–OP12)OP07 Previous exacerbation is the most important risk factor for future exacerbations in school-age children with asthmaS. Tolga Yavuz, Guven Kaya, Mustafa Gulec, Mehmet Saldir, Osman Sener, Faysal GokOP08 Comparative study of degree of severity and laboratory changes between asthmatic children using different acupuncture modalitiesNagwa Hassan, Hala Shaaban, Hazem El-Hariri, Ahmed Kamel Inas E. MahfouzOP09 The concentration of exhaled carbon monoxide in asthmatic children with different controlled stadiumPapp Gabor, Biro Gabor, Kovacs CsabaOP10 ...
Backround and aimsHousehold products are one of the most important category responsable for paediatric toxic exposure, especially in children younger then 6 years old. The aims of this study were to analize the epidemiological characteristics of paediatric exposures to packet and nonpacket forms of liquid detergents and to identify the most frequent clinical findings associated with this type of exposures.MethodsWe performed a five year retrospective study between January 1 st, 2012 and December 31 st, 2016 of all cases with liquid detergent poisoning admitted to the Toxicology Department in the Clinical Emergency Hospital for Children „Grigore Alexandrescu ’ from Bucharest.ResultsA total of 231 cases involving liquid detergents were recorded, including 166 cases of laundry liquid detergents and 65 exposures to other types of liquid detergents. The packet forms of laundry detergents were the most commonly identified (131 cases, 56.7%)Boys (131 cases) were more frequently exposed than girls (100 cases). Regarding the age, most patients belonged to the age group 1–5 years (190 cases, 82.25%), followed by patients younger than 1 year (23 de cases, 9.95,%), those aged 6 to 10 years (11 cases, 4.76%) and 11 to 18 years (7 cases,3.03% ). The mean age of the patients exposed was 2.7 years.85.7% of the patients were symptomatic after exposure, clinical manifestations depending on the route of exposure. In case of ingestion, gastrointestinal symptoms were most commonly noted. Vomiting were present in 180 cases (77.9%), causing acute dehydration in 36 cases. Dysphagia was noted in 41 of the analysed cases, abdominal pain in 11 cases and diarrhoea and hematemesis in 2 cases each. Coughing was noted in 25 patient (10.8%), of which 7 were diagnosed with chemical laryngitis and 9 with chemical pneumonia. Dermal exposure was associated to ingestion in 6 patients and determined oral irritation or oral burns and lips oedema.Ocular exposure occurred in 11 patients (4.76%) causing conjunctivitis, keratitis or corneal burns.ConclusionsExposures to packed forms of liquid laundry detergents were much more common than laundry detergents nonpacket or other types of liquid detergents exposures. Clinical manifestations depended on the route of exposure: ingestion, ocular or dermal and the severity of clinical effects ranged between no symptoms to severe form of hematemesis, acute dehydration and chemical pneumonia.
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