The first synthesis of symmetrical and dissymmetrical conjugated triynes by self- and cross-metathesis was successfully achieved thanks to the use of hindered diynes.
An efficient and general iodocarbamation of benzyl N‐homopropargylcarbamates has been developed by using iodine as the electrophilic agent. This regio‐ and stereoselective cyclization yielded (E)‐6‐iodomethyleneoxazinan‐2‐ones, which can be further transformed through palladium cross‐coupling reactions followed by hydrogenation to produce 1,3‐oxazinan‐2‐ones.
In memory of François DiederichKinetically unstable isocyanides as vinyl, allenyl and propargyl isocyanides react in Passerini and Ugi reactions faster than they decompose and lead to functionalized α-acyloxy amides and αamino amides, respectively, which can subsequently be used in reactions involving the unsaturated substituent.
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