Identifying and developing high potential individuals is fundamental to successful companies and organizations. The present study focuses on the personality traits of high potential individuals. The High Potential Traits Inventory (HPTI) was used to investigate associations between personality traits and measures of career success, in a sample of 383 employed individuals. Results indicate HPTI personality traits relate to subjective and objective measures of success with Conscientiousness being the strongest predictor. The findings of the current study are consistent with previous research on High Flyers. Implications of the current study are discussed, suggesting a clearer operationalization of success is crucial for understanding the underlying mechanisms which lead from personality to potential. wileyonlinelibrary.com/journal/ijsa
Klebsiella
is a leading cause of health care-associated infections. Patients who are intestinally colonized with
Klebsiella
are at a significantly increased risk of subsequent infection, but only a subset of colonized patients progress to disease.
Members of the Klebsiella pneumoniae species complex frequently colonize the gut and colonization is associated with subsequent infection. To identify genes associated with progression from colonization to infection, we undertook a case-control comparative genomics study. Concordant cases (N = 85), where colonizing and invasive isolates were identical strain types, were matched to asymptomatically colonizing controls (N = 160). Thirty-seven genes are associated with infection, 27 of which remain significant following adjustment for patient variables and bacterial phylogeny. Infection-associated genes are not previously characterized virulence factors, but instead a diverse group of stress resistance, regulatory and antibiotic resistance genes, despite careful adjustment for antibiotic exposure. Many genes are plasmid borne, and for some, the relationship with infection is mediated by gut dominance. Five genes were validated in a geographically-independent cohort of colonized patients. This study identifies several genes reproducibly associated with progression to infection in patients colonized by diverse Klebsiella.
Klebsiella frequently colonizes the gut and colonization is associated with subsequent infection. To identify genes associated with progression from colonization to infection, we undertook a case-control comparative genomics study. Concordant cases (N = 85), where colonizing and invasive Klebsiella isolates were identical strain types, were matched to asymptomatically colonizing controls (N = 160). Thirty-seven genes were significantly associated with infection, 27 of which remained significant following adjustment for patient variables and bacterial phylogeny. Infection-associated genes were not previously characterized virulence factors, but instead a diverse group of stress resistance, regulatory and antibiotic resistance genes, despite careful adjustment for antibiotic exposure. Many infection-associated genes were plasmid borne, and for some, the relationship with infection was mediated by gut dominance. Five infection-associated genes were validated in a geographically independent cohort of colonized patients. This study identifies novel genes that are reproducibly associated with progression to infection in patients colonized by diverse Klebsiella.
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