We applied terahertz (THz)-pulsed spectroscopy to study ex vivo the refractive index and absorption coefficient of human brain gliomas featuring different grades, as well as perifocal regions containing both intact and edematous tissues. Glioma samples from 26 patients were considered and analyzed according to further histological examination. In order to fix tissues for the THz measurements, we applied gelatin embedding, which allows for sustaining their THz response unaltered, as compared to that of the freshly excised tissues. We observed a statistical difference between the THz optical constants of intact tissues and gliomas of grades I to IV, while the response of edema was similar to that of tumor. The results of this paper justify a potential of THz technology in the intraoperative label-free diagnosis of human brain gliomas for ensuring the grosstotal resection.
ОбзОры
История применения эндоскопической техники удаления грыж межпозвонковых дисков поясничного отдела позвоночникаПервое сообщение о возможности эндоскопии в спи-нальной хирургии сделано M. Burman [1], использовав-шим эндоскоп диаметром 9,5 мм для осмотра конского хвоста на трупах. Автор пришел к выводу, что техническое несовершенство оборудования не позволяет использовать эндоскопию в клинике, но прогнозировал возможность применения данного метода с целью уточнения диагноза.L. Pool [2] использовал модифицированный отоскоп с освещением для обследования корешков при грыже диска и при некоторых других видах патологии позвоночного канала. Впервые эндоскопическую биопсию ткани меж-
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