Differentiation of healthy and malignant brain tissues using terahertz pulsed spectroscopy and optical coherence tomography

Chernomyrdin, Nikita V.; Dolganova, Irina N.; Aleksandrova, P. V.; Musina, Guzel R.; Malakhov, Kirill M.; Никитин, П.В.; Kosyrkova, Alexandra; Komandin, G. A.; Reshetov, Igor V.; Потапов, А А; Tuchin, Valery V.; Zaytsev, Kirill I.

doi:10.1117/12.2506600

Cited by 5 publications

(5 citation statements)

References 57 publications

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“…Tumors were clearly seen on the GFP and PpIX fluorescence images, though weakly developed tumors demonstrated low fluorescence intensity; OCT images provided detailed information about the brain tissue structure, but distinct tumor regions could not be visualized. In [451], an approach for intraoperative neurodiagnosis based on TPS and OCT was proposed; it was shown that TPS can be applied to differentiate gliomas and normal brain tissues, while OCT can be utilized to discriminate between high-grade and low-grade gliomas.…”

Section: Multiplexing Different Label-free Imaging Modalities To Impr...mentioning

confidence: 99%

The progress and perspectives of terahertz technology for diagnosis of neoplasms: a review

Zaytsev

Dolganova

Chernomyrdin

et al. 2019

J. Opt.

161

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Over the past few decades, significant attention has been paid to the biomedical applications of terahertz (THz) technology. Nowadays, THz spectroscopy and imaging have allowed numerous demanding problems in the biological, medical, food, plant and pharmaceutical sciences to be solved. Among the biomedical applications, the label-free diagnosis of malignant and benign neoplasms represents one of the most attractive branches of THz technology. Despite this attractiveness, THz diagnosis methods are still far from being ready for use in medical practice. In this review, we consider modern research results in the THz diagnosis of malignant and benign neoplasms, along with the topical research and engineering problems which restrain the translation of THz technology to clinics. We start by analyzing the common models of THz-wave-tissue interactions and the effects of tissue exposure to THz waves. Then, we discuss the existing modalities of THz spectroscopic and imaging systems, which have either already been applied in medical imaging, or hold strong potential. We summarize the earlier-reported and original results of the THz measurements of neoplasms with different nosology and localization. We pay attention to the origin of contrast between healthy and pathological tissues in the THz spectra and images, and discuss the prospects of THz technology in

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Section: Multiplexing Different Label-free Imaging Modalities To Impr...mentioning

confidence: 99%

The progress and perspectives of terahertz technology for diagnosis of neoplasms: a review

Zaytsev

Dolganova

Chernomyrdin

et al. 2019

J. Opt.

161

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“…Multimodal diagnosis. The combination of several diagnostic approaches, integrated together in one complex diagnostic system, possesses high efficiency in clinical practice 231 . For instance, the combination of TPI, MRI, OCT, fluorescence imaging relying on green fluorescence protein (GFP) and protoporphyrin IX (PpIX), white light imaging and H&E-stained histology make it possible to more clearly define the boundaries of brain tumors, perifocal zone, as well as to evaluate the molecular properties and the degree of pathohistological malignancy of the neoplasm 85 .…”

Section: Prospects and Challenging Problemsmentioning

confidence: 99%

Terahertz technology in intraoperative neurodiagnostics: A review

Chernomyrdin¹,

Musina²,

Никитин³

et al. 2023

OEA

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Terahertz (THz) technology offers novel opportunities in biology and medicine, thanks to the unique features of THzwave interactions with tissues and cells. Among them, we particularly notice strong sensitivity of THz waves to the tissue water, as a medium for biochemical reactions and a main endogenous marker for THz spectroscopy and imaging. Tissues of the brain have an exceptionally high content of water. This factor, along with the features of the structural organization and biochemistry of neuronal and glial tissues, makes the brain an exciting subject to study in the THz range. In this paper, progress and prospects of THz technology in neurodiagnostics is overviewed, including diagnosis of neurodegenerative disease, myelin deficit, tumors of the central nervous system (with an emphasis on brain gliomas), and traumatic brain injuries. Fundamental and applied challenges in study of the THz-wave -brain tissue interactions and development of the THz biomedical tools and systems for neurodiagnostics are discussed.

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“…The penetration depth of THz and OCT, which are both on the scale of millimeters or less in most materials, including biological tissues, tends to guide the nature of these applications. Some of the areas showing potential are near-surface (epithelial) or intra-operative cancer imaging [12][13][14][15], skin hydration changes [16,17], corneal hydration [18,19], pharmaceutical quality control [20,21] and cultural heritage [22][23][24][25][26][27]. There are possible applications where combining the techniques and overlaying complementary properties of structure and morphology from OCT with functionality and hydration properties from THz imaging, may lead to improved diagnostic sensitivity and specificity.…”

Section: Introductionmentioning

confidence: 99%

“…Previous researchers have proposed that imaging a sample using THz and OCT may be of benefit for diagnosis [30]; however, as yet there have been no studies that combined the two. For example, Chernomyrdin et al [14] used both OCT and THz to examine malignant brain tissue, but did so separately and did not use either OCT to inform the THz properties, or vice versa. They do propose 'multiplexing the information' without providing methods to do so.…”

Section: Introductionmentioning

confidence: 99%

Co-registered combined OCT and THz imaging to extract depth and refractive index of a tissue-equivalent test object

Fitzgerald

Tie

Hackmann

et al. 2020

Biomed. Opt. Express

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Terahertz (THz) imaging and optical coherence tomography (OCT) provide complementary information with similar length scales. In addition to OCT's extensive use in ophthalmology, both methods have shown some promise for other medical applications and non-destructive testing. In this paper, we present an iterative algorithm that combines the information from OCT and THz imaging at two different measurement locations within an object to determine both the depth of the reflecting layers at the two locations and the unknown refractive index of the medium for both the OCT wavelengths and THz frequencies. We validate this algorithm using a silicone test object with embedded layers and show that the depths and refractive index values obtained from the algorithm agreed with the measured values to within 3.3%. We further demonstrate for the first time that OCT and THz images can be co-registered and aligned using unsupervised image registration. Hence we show that a combined OCT/THz system can provide unique information beyond the capability of the separate modalities alone, with possible applications in the medical, industrial and pharmaceutical sectors.

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Differentiation of healthy and malignant brain tissues using terahertz pulsed spectroscopy and optical coherence tomography

Cited by 5 publications

References 57 publications

The progress and perspectives of terahertz technology for diagnosis of neoplasms: a review

The progress and perspectives of terahertz technology for diagnosis of neoplasms: a review

Terahertz technology in intraoperative neurodiagnostics: A review

Co-registered combined OCT and THz imaging to extract depth and refractive index of a tissue-equivalent test object

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