Background and Purpose-Accurate estimates for risk and rates of intracranial hemorrhage (ICH)

Experts have argued about the clinical significance of these aneurysms, which may be important for risk stratification in patient management and clinical trials. We studied the association between coexisting aneurysms and initial presentation with intracranial hemorrhage (ICH) in patients with BAVM evaluated at two tertiary-care centers. Methods-Demographic and clinical data were collected from a prospective series of patients evaluated for BAVM at the University of California, San Francisco (UCSF; nϭ82), and Columbia-Presbyterian Medical Center, New York (CPMC; nϭ254). Using multivariate logistic regression, we examined the independent association between ICH presentation and the presence of a coexisting aneurysm, and compared the association at the two hospitals. Results-Aneurysms were associated with 28 BAVMs at UCSF (34%) and 74 at CPMC (29%; Pϭ0.39). Initial presentation with ICH was associated with the presence of a coexisting aneurysm at CPMC (odds ratio 1.8, 95% confidence interval 1.0 to 3.0, Pϭ0.044). The opposite trend was observed at UCSF (odds ratio 0.4, 95% confidence interval 0.2 to 1.1, Pϭ0.085). We observed an interaction by site involving the association between ICH presentation and aneurysm (Pϭ0.016). Conclusion-Although many BAVM characteristics were similar at the referral centers studied, the association between initial presentation with ICH and coexisting aneurysms was not. This heterogeneity between populations undermines the validity of inferences on the role of aneurysms from any single referral series, and emphasizes the complexity in creating BAVM risk-stratification models that incorporate aneurysms. (Stroke. 2002;33:675-679.)