Longitudinal Risk of Intracranial Hemorrhage in Patients With Arteriovenous Malformation of the Brain Within a Defined Population

Halim, Alexander X.; Johnston, S. Claiborne; Singh, Vineeta; McCulloch, Charles E.; Bennett, John P.; Achrol, Achal S.; Sidney, Stephen; Young, William L.

doi:10.1161/01.str.0000130988.44824.29

Cited by 240 publications

(149 citation statements)

References 21 publications

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“…6,13,14,16,40 Furthermore, recent studies of Halim et al, 14 Yamada et al, 40 da Costa et al, 6 and Hernesniemi et al 15 have shown relatively elevated annual rehemorrhage rates of 5-6% up to 5 years after an initial hemorrhagic presentation.…”

Section: Risk Factors For Hemorrhagementioning

confidence: 97%

Posterior fossa arteriovenous malformations

Arnaout¹,

Gross

Eddleman³

et al. 2009

FOC

115

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Arteriovenous malformations (AVMs) of the posterior fossa are complex neurovascular lesions that are less common than their supratentorial counterparts, accounting for < 15% of all AVMs. The majority of patients with these lesions present with intracranial hemorrhage, a factor that has been consistently shown to increase one's risk for subsequent bleeding. Studies have additionally shown a posterior fossa or deep AVM location to portend a more aggressive natural history. The authors reviewed the literature on posterior fossa AVMs, finding their annual rupture rates to be as high as 11.6%, an important factor that underscores the importance of aggressive treatment of lesions amenable to intervention as therapeutic options and results continue to improve.

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Section: Risk Factors For Hemorrhagementioning

confidence: 97%

Posterior fossa arteriovenous malformations

Arnaout¹,

Gross

Eddleman³

et al. 2009

FOC

115

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“…For the BAVM natural history study, the most valid follow-up model is to use the time from diagnosis to an event. 8,9,31 However, investigators from our study group and other institutes have also reported the hemorrhage rate on the basis of a follow-up method that assumes that the lesion is present from birth and has a subsequent constant annual hemorrhage risk (On-line Table 5). 16,[32][33][34][35] A recent study comparing the 2 approaches suggested that the latter follow-up method is a valid alternative for a BAVM natural history study.…”

Section: Study Limitationsmentioning

confidence: 99%

Periventricular Location as a Risk Factor for Hemorrhage and Severe Clinical Presentation in Pediatric Patients with Untreated Brain Arteriovenous Malformations

Ma¹,

Huang²,

Chen³

et al. 2015

AJNR Am J Neuroradiol

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“…There does not appear to be a gender predilection. They most commonly present with hemorrhage; many population-based studies and large natural history studies demonstrate that approximately 50% of patients present with AVM rupture [40][41][42][43][44][45][46][47][48][49][50][51]. The next most common presenting feature is seizure, with 24-36% of patients presenting with generalized or partial seizures.…”

Section: Clinical Featuresmentioning

confidence: 99%

“…Without treatment, the overall risk of AVM hemorrhage has been estimated to be 2 to 4.6% per year [40][41][42][43][44][45][46]. Previous hemorrhage is a significant risk factor for further hemorrhage; the risk may be as high as 18% in the first year after hemorrhagic presentation [62], returning to baseline within 5 years [63].…”

Section: Prognosismentioning

confidence: 99%