Aim: The research was aimed to analyze a level of triglycerides in blood serum as a possible new marker of toxicity, particularly in patients with excess body weight, receiving cisplatin. Materials and Methods: Study involved 20 oncological patients with stage III lung cancer, who received palliative treatment with cisplatin. High-performance liquid chromatography was used for quantitative determination of pure cisplatin in urine and blood samples. Cisplatin concentration of the test samples was determined based on the data obtained from the calibration graph. Results: Quantitative determination of pure cisplatin is quite complicated. The elimination half-time for one of the groups was observed higher almost by half than for other patients. Higher dose of cisplatin showed a significant association with increase in triglyceride levels. We found a close correlation between body mass index and triglyceride changes during chemotherapy (p = 0.001; r = 0.67). The results indicate that a higher body mass index gives higher fluctuations of triglyceride levels in blood serum. Analyses of correlation between level of triglycerides and elimination half-time show that by an increase in the level of triglycerides in the blood serum cisplatin elimination half-time is prolonged (R2 Linear = 0.596). Cisplatin concentration in urine is higher and elimination takes longer time at elevated levels of triglycerides, where close correlation between fraction of excreted substance in urine and concentration parameters was seen (p < 0.01). Also good correlation for body mass index with fraction of excreted substance in urine and concentration parameters was observed (p < 0.05). Conclusion: Clearance of cisplatin, which was determined by the chromatographic method, is reduced in individuals with increased adipose tissue mass. Research data suggest that overweight affects cisplatin elimination from the body. The greater body fat mass can contribute to a greater rise of triglyceride level in blood serum. Triglycerides in blood plasma may serve as an additional indicator of higher cisplatin toxicity as a cardiotoxicity marker.

This study explored new possibilities for measuring the sense of belonging to the country and investigated predictors of the sense of belonging to Latvia. Focusing on students’ sense of belonging to the country is explained by two reasons: 1) emigration is the main factor of depopulation in Latvia; 2) students’ intention to emigrate is the highest among other social groups. Studies in the field of community psychology present models of the sense of community and explore intentions to stay in a particular place. Within a new model, different levels of social systems (from meso- to macro-system) were included into the analysis of predictors of the sense of belonging to the country. The participants were 205 university students from 18 to 30 (67% females). On the basis of previous studies, a new measure of the sense of belonging and perceived context was developed. The results confirmed a complex model of the sense of belonging in the context of social systems. Higher perceived opportunities at the level of the country and more positive evaluation of the future of Latvia predicted higher level of the sense of belonging to Latvia directly. In addition, female students perceived higher level of the sense of belonging than male students.

The satisfaction of the need to belong reflects in the sense of being an integrative part of the group or social system. There is some lack of empirical evidence for the structure of this sense at the macro level. This study assessed a two-dimensional model of the sense of belonging to the country, which included relational and spatiotemporal components. Participants were 539 university students from 18 to 50 (74% females). Questions regarding involvement, perceived acceptance, sense of commonality, and feeling at home represented the relational component of the sense of belonging. Four temporal categories—the recent past, present, and the near and distant future—were included in the assessment of its spatiotemporal component. A confirmatory factor analysis revealed an acceptable fit of the two-factor model. Its convergent validity was demonstrated by the association with an explicit single-item measure of belonging. The predictive effect of the spatiotemporal component emphasized the importance of continuity of belonging in considering emigration. In sum, the results confirmed the complexity of the sense of belonging to the country and the interconnectedness of integrative relationships and spatiotemporal commitment and revealed functional differences between them.

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Background Studies on a new coronavirus disease (COVID-19) show the elevation of liver enzymes and liver fibrosis index (FIB-4) independently on pre-existing liver diseases. It points to increased liver fibrogenesis during acute COVID-19 with possible long-term consequences. This study aimed to assess liver fibrosis in COVID-19 patients by serum hyaluronic acid (HA) and FIB-4. Methods The study included the acute COVID-19 group (66 patients, 50% females, mean age 58.3 ± 14.6), the post-COVID group (58 patients in 3–6 months after the recovery, 47% females, mean age 41.2 ± 13.4), and a control group (17 people, 47% females, mean age 42.8 ± 11.0). Ultrasound elastography was performed in the post-COVID and control groups. Results Sixty-five percent of the acute COVID-19 group had increased FIB-4 (> 1.45), and 38% of patients had FIB-4 ≥ 3.25. After matching by demographics, 52% of acute COVID-19 and 5% of the post-COVID group had FIB-4 > 1.45, and 29% and 2% of patients had FIB-4 ≥ 3.25, respectively. Increased serum HA (≥ 75 ng/ml) was observed in 54% of the acute COVID-19 and 15% of the post-COVID group. In the acute COVID-19 group, HA positively correlated with FIB-4, AST, ALT, LDH, IL-6, and ferritin and negatively with blood oxygen saturation. In the post-COVID group, HA did not correlate with FIB-4, but it was positively associated with higher liver stiffness and ALT. Conclusion More than half of acute COVID-19 patients had increased serum HA and FIB-4 related to liver function tests, inflammatory markers, and blood oxygen saturation. It provides evidence for the induction of liver fibrosis by multiple factors during acute COVID-19. Findings also indicate possible liver fibrosis in about 5% of the post-COVID group.

This study examined the sense of belonging to Latvia in Latvian-speaking and Russianspeaking residents of Latvia. The structural model involved opportunities for the fulfillment of personal goals and views of the situation in Latvia and the community as predictors of the sense of belonging at both levels of ecological systems. The Russianspeaking subsample consisted of 202 students ranging in age from 18 to 36 (65% females). The Latvian-speaking subsample involved 438 students ranging in age from 18 to 37 (67% females). The Sense of Belonging in Social Context Questionnaire and the Future of Country Questionnaire were applied. Belonging to community predicted belonging to Latvia in both groups of residents. However, the Russian-speaking minority group demonstrated more signs of local belonging and pragmatic ties with Latvia. Providing opportunities for fulfilment of personal goals and facilitating involvement of young people in processes at the country level are challenges for policies, aimed at integration and limiting emigration of young people.

This cross-cultural study explored subjective predictors of more positive evaluation of the future of the country during a global socioeconomic crisis. A sequential mixed-method design was chosen for an exploration of students? expectations in Russia and Latvia as countries contrasting in macro-contextual conditions. In 2009, Study 1 was designed as a thematic analysis of essays on topic ?The Future of Latvia/Russia?. The results demonstrated that the future of a country is anticipated by taking into account external influences, the present of the country, and its perceived power and stability. In 2011, Study 2 involved these themes as independent variables in a multiple regression model. The results demonstrated that positive evaluation of the present and higher perceived power of the country are individuallevel predictors of more positive evaluation of its future. Observed concordance of models indicates relatively high importance of subjective view of the country in the changing world.

The pelvis and the spine form a system balancing human skeleton. Within this system, the pelvis adapts to age-related changes in the spine. Previous studies were predominantly focused on changes of pelvic parameters in the sagittal plane. The aim of this study was to reveal age-related changes of lesser pelvic dimensions at different levels of the pelvic cavity in the sagittal and coronal planes and to explore sexual dimorphism in age-related tendencies. The computed tomography pelvimetry was performed on the three-dimensional workstation. The research sample included 211 females aged 18 to 84 years and 181 males aged 18 to 82 years, who underwent an examination at the Riga East University Hospital, Clinical Center “Gailezers,” Latvia. Three pelvic angles and transverse and sagittal diameters of the lesser pelvis were measured at four levels: the inlet, two axial planes in the mid-cavity, and the outlet. The results demonstrated that more pronounced age-related changes occurred in the inlet and the outlet of the lesser pelvis. The mid-cavity was less changing. The transverse diameter between acetabular centers and the sagittal diameter at the level of ischial spines were independent of age. In general, the common age-related trends were observed for pelvic parameters in females and males. A single exception was the proportion of diameters at the level of ischial spines, which decreased in males only. For parameters associated with pelvic floor diseases, age-related changes occurred in the direction of pathology.