Objective. Objective of this research was to examine which factors were related to depression, anxiety and stress among nurses/technicians, professional studies students. Methods. A cross-sectional study was conducted among students of the High Medical School of Professional Studies in (p = 0,020; p = 0,001; p = 0,001), radnog statusa (p = 0,007; p = 0,020; p = 0,005), ukupan radni staž (p = 0,049; p = 0,051; p = 0,017), zatim osećaja zadovoljstva sobom kao studentom (p = 0,000; p = 0,021; p = 0,004). Postojala je statistički značajna razlika u prosečnim vrednostima stres skale u odnosu na motiv za upis u školu (F = 6,445; p < 0,05). Prosečne vrednosti stres skale bile su najveće kod ispitanika čiji je motiv bio obezbeđenje radnog mesta, a najniže kod ispitanika čiji je motiv bio napredovanje u struci.Zaključak. Rezultati istraživanja ukazuju na značaj ranog sagledavanja problema mentalnog zdravlja radi iznalaženja i razvijanja adekvatnih programa prevencije i promocije usmerenih ka unapređenju mentalnog zdravlja i kvaliteta života.

Introduction/Objective Although effectiveness of atypical antipsychotics in patients with schizophrenia is mostly similar, there are significant differences in adverse effects rate and treatment costs, making comparison of their cost/effectiveness ratios essential for optimal drug choice. The aim of this study was to compare cost/effectiveness of aripiprazole and olanzapine in long-term treatment of schizophrenia. Methods A four-state, three-month cycle Markov model was built to compare aripiprazole and olanzapine. The model assumed that patients who relapse on treatment with both aripiprazole and olanzapine are further treated with clozapine. The perspective of the National Health Insurance Fund was chosen, and the period covered by the model was 10 years. The model results were obtained after Monte Carlo microsimulation of a sample with 1,000 virtual patients. Both multiple one-way and probabilistic sensitivity analysis was made. Results After base-case analysis aripiprazole was dominated by olanzapine, as net monetary benefit was negative 341.96 ± 29,131.53 RSD) and incremental cost/effectiveness ratio (ICER) was above the willingness-to-pay line of one Serbian gross domestic product per capita per quality-adjusted life year (QALY) gained. Multiple one-way and probabilistic sensitivity analysis confirmed results of the base case simulation. Conclusion Olanzapine has more beneficial cost/effectiveness ratio than aripiprazole for long-term treatment of schizophrenia in Serbian milieu.

Introduction/Objective. Previous studies suggest that number of suicides and suicide attempts will increase due the COVID-19 pandemic. The aim of this study was to investigate the impact of the COVID-19 pandemic on the frequency and characteristics of suicide attempts in the Republic of Serbia. Methods. The study observed two periods: the period from March to August 2020 (the COVID period) and the same period of the previous year (the non-COVID period). The observation during the mentioned periods encompassed patients who were examined at the Dr. Laza Lazarevic Clinic for Mental Disorders in Belgrade due to suicide attempts (1987 persons during COVID period and 2300 persons during non-COVID period). Results. Concerning suicide attempts, a statistically significant difference between the observed periods was registered in respect of total number of monthly clinical examinations, monthly distribution of suicide attempts, patients? gender and age, mode of suicide attempt and the diagnostic category. Binary logistic regression determined that statistically significant factors that can influence the suicide attempt were year, months, patients? gender and age, and diagnostic category. Conclusion. COVID-19 pandemic creates the increased exposure of the people to suicide risk factors, which points to the significance of consistent monitoring of mental health during the COVID-19 pandemic and thereafter.

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Schizophrenia is one of the most seriouspsychiatric illnesses belonging to the group of non-affective psychoses. It is characterized by distortions of thought, perception, emotions and behavior. Twenty-four million people around the world suffer from schizophrenia. Schizophrenia is a chronic illness connected to significant expenses which are imposed on both the health system, extended social community and family, as well.Cost of illness studies of schizophrenia conducted around the world show wide range of material resources that countries set aside from their health budgets in order to cure schizophrenia. They range from 1.6% to 2.5%.International cost of illness studies came to the conclusion that the costs of this disease are high, depending on the health system and location and that intangible costs per se already justify investments in research and development of new treatments.Majority of published papers suggest that atypical antipsychoticshave better cost-effectiveness profile in comparison to the first generation of antipsychotics. Olanzapine, clozapine and risperidone are atypical antipsychotics generally found to be most costeffective in treating schizophrenia.

Rett syndrome is a neurodevelopmental disorder caused by mutation in the gene MECP2 on the X chromosome. The main clinical characteristics are breathing disorders, epileptic seizures, scoliosis, walking disability and constipation with frequent growth failure and malnutrition. Our transversal study included 29 female patients with Rett syndrome treated in the Institute for Mother and Child Health Care ''Dr Vukan Čupić'' in Belgrade. The patients were anthropometrically measured by their height and weight and caluculating body mass index. The degree of scolisios, the frequency of epileptic seizures, walking ability and grade of respiratory dysfunction were assessed based on the clinical scales for disease severity estimation. The statistical data analysis was done in the software package PASW Statistics 18. The average age of the patients was 145.5±90.1 months. The average height was 125.2±22.1cm, the average weight 27.6±12.3kg, and the average body mass index was 16.6±3.5kg/m 2. The average z scores for height, weight and BMI-for-age were statistically significantly lower in comparison to general population, which is given with negative z scores. There was the statistically significant negative coorelation between the age of patients and the average z scores for height-for-age (r=-0.464 p=0.011), weight-for-age (r=-0.433 p=0.019) and BMI-for-age (r=-0.433 p=0.019). The statistically significant negative coorelation was found between the degree of scoliosis and the average z scores for height and weight-for-age, but not with the average z score for BMI-for-age.The growth failure and malnutrition represent significant problems which are found in Rett syndrome. The detection of factors affecting the growth and nutrition in patients with Rett syndrome could greatly contribute to the improvement of the quality of life in the patients with Rett syndrome and perhaps lead to the correction of the approach of symptomatic and supportive therapy.