In modern medicine, the issue of combating biofilms, including various surfaces in medical facilities, is acute. Ozonation is an environmentally friendly and effective technology in the fight against microbial pollution, including biofilms. The article presents studies of the disinfecting properties of ozone and its combination with various disinfectants on planktonic and adhered (in the biofilm form) Pseudomonas aeruginosa cells. As a result, it was found that ozone is highly effective against various forms of bacterial life, and also requires longer exposure in the presence of organic pollution. When combined with hydrogen peroxide, it shows the greatest bactericidal effect not only on the destruction of the biofilm, but also on the viability of the cells themselves. Keywords: biofilm, ozone disinfection, destruction of biofilm.
The search for new substances capable of inhibiting the growth of microorganisms is relevant. Therefore, an assessment was made of the effect of carbon nanoparticles on the growth and biofilm formation of microbial isolates from the surfaces of anthropogenic environmental objects. It has been established that carbon nanoparticles on the C60 + PVP + AC960 diamond platform are able to suppress the growth, reproduction and ability to biofilm formation of gram-positive and gram-negative prokaryotes, as well as fungi of the genus Candida and Aspergillus. Under the influence of C60+AC960 fullerenes, the biofilm-generation ability of Staphylococcus epidermidis, Bacillus cereus, Escherichia coli, and Candida albicans was significantly inhibited. These data provide a basis for further study of these compounds as a promising antimicrobial agent. Keywords: Antimicrobial action, carbon nanoparticles, biofilm formation, fullerenes, nanodiamonds.
The studied conditions for infection with hemorrhagic fever with renal syndrome, which occupies a leading place in Russia among all natural focal infections, mainly relate to forest and forest-steppe landscapes, while the conditions for infection of the population in the steppe remain poorly understood. The purpose of the work is to determine the conditions for infection with hemorrhagic fever with renal syndrome in the population of the forest-steppe and steppe landscapes using the example of the Orenburg region. Puumala hantavirus circulates in the region. 731 maps of the epidemiological examination of the epidemic focus of zoonoses were studied. The study showed that in the forest-steppe landscape, in comparison with the steppe, infection of the population occurs more often during work on a personal plot, as well as in everyday life at the place of residence from small mammals or environmental objects. In the steppe landscape, in contrast to the forest-steppe, infection with hantaviruses is more often observed during fishing and when resting in the forest. Keywords: hemorrhagic fever with renal syndrome, forest-steppe and steppe landscapes, infection conditions.
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