GUADARRAMA-ORTIZ RESUMEN:El núcleo supraquiasmático (NSQ) es el principal reloj biológico de los mamíferos y sincroniza la actividad de la glándula pineal al ciclo luz-oscuridad a través de una vía polisináptica. El efecto de asa de retroalimentación neuroendocrina se lleva a cabo por la melatonina. El presente trabajo pretende demostrar que la glándula pineal modula la sensibilidad a la luz en el NSQ. Se utilizaron ratas Wistar, y se asignaron a 3 grupos: grupo A (falsa pinealectomía -sham-, sin luz), grupo B (falsa pinealectomía -sham-+ luz) y grupo C al cual se le realizó la pinealectomía + luz, después de la manipulación se sacrifican para realizar inmunohistoquímica para c-Fos y al final conteo celular por técnica de estereología. Se obtuvo una reducción del 46,8% del promedio de células inmunorreactivas a c-Fos en el grupo C en comparación del grupo B. Este trabajo muestra que la sensibilidad a la luz está modulada por la actividad de la glándula pineal.
The common characteristics that make scaffolds suitable for human tissue substitutes include high porosity, microscale features, and pores interconnectivity. Too often, however, these characteristics are limiting factors for the scalability of different fabrication approaches, particularly in bioprinting techniques, in which either poor resolution, small areas, or slow processes hinder practical use in certain applications. An excellent example is bioengineered scaffolds for wound dressings, in which microscale pores in large surface-to-volume ratio scaffolds must be manufactured – ideally fast, precise, and cheap, and where conventional printing methods do not readily meet both ends. In this work, we propose an alternative vat photopolymerization technique to fabricate centimeter-scale scaffolds without losing resolution. We used laser beam shaping to first modify the profile of the voxels in 3D printing, resulting in a technology we refer to as light sheet stereolithography (LS-SLA). For proof of concept, we developed a system from commercially available off-the-shelf components to demonstrate strut thicknesses up to 12.8 ± 1.8 μm, tunable pore sizes ranging from 36 μm to 150 μm, and scaffold areas up to 21.4 mm × 20.6 mm printed in a short time. Furthermore, the potential to fabricate more complex and three-dimensional scaffolds was demonstrated with a structure composed of six layers, each rotated by 45° with respect to the previous. Besides the demonstrated high resolution and achievable large scaffold sizes, we found that LS-SLA has great potential for scaling-up of applied oriented technology for tissue engineering applications.
Maxillary trigeminal schwannoma must be suspected if vague sinunasal symptoms, paranasal mass or, as in this case, trigeminal neuralgia present. Surgical treatment is indicated, and approaches vary according to location and tumour size.
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