Coronavirus disease 2019 (COVID-19) is triggered by the SARS-CoV-2, which is able to infect and cause dysfunction not only in lungs, but also in multiple organs, including central nervous system, skeletal muscle, kidneys, heart, liver, and intestine. Several metabolic disturbances are associated with cell damage or tissue injury, but the mechanisms involved are not yet fully elucidated. Some potential mechanisms involved in the COVID-19-induced tissue dysfunction are proposed, such as: (a) High expression and levels of proinflammatory cytokines, including TNF-α IL-6, IL-1β, INF-α and INF-β, increasing the systemic and tissue inflammatory state; (b) Induction of oxidative stress due to redox imbalance, resulting in cell injury or death induced by elevated production of reactive oxygen species; and (c) Deregulation of the renin-angiotensin-aldosterone system, exacerbating the inflammatory and oxidative stress responses. In this review, we discuss the main metabolic disturbances observed in different target tissues of SARS-CoV-2 and the potential mechanisms involved in these changes associated with the tissue dysfunction.
of all 38 analytes. A good correlation between the fluorescent and visible acquisition modes (R 2 ¼0.88) was found. Conclusions: Plasmonic fluor is an enabling technology to immediately improve the sensitivity of existing methodologies such as microarrays in an easy-to-implement and cost-effective manner. There is applicability of this nanoconstruct as a "visible label" in resource-limited settings to alleviate reliance on immobile and expensive fluorescence readout instruments thus enabling clinical outreach to underserved populations worldwide to diagnose acute kidney injury as a point-of-service assay.
Este estudo tem como objetivo compreender as contribuições da Língua Brasileira de Sinais - LIBRAS para a vida e formação da pessoa surda no processo de construção do conhecimento e autonomia. Trata-se de uma pesquisa qualitativa, tendo como metodologia a pesquisa (auto)biográfica como instrumento de investigação por meio das narrativas de um sujeito surdo. Os resultados apontaram que a LIBRAS proporcionou a pessoa surda uma construção do conhecimento e autonomia, com esse conhecimento a pessoa surda ressignificou momentos de superação a partir da reconstrução de si na convivência com o outro no seu dia a dia, oportunizando refazer seu caminho de vida e formação. Com base nas histórias de vida e formação do sujeito, as narrativas (auto)biográficas nortearam a compreensão de como ocorre a inserção do sujeito surdo no seu cotidiano, e abre um leque de possibilidades para futuros questionamentos acerca do processo de inclusão do sujeito surdo na sociedade, propiciando a (auto)formação construída no processo de (auto)conhecimento de si.
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