Molecular and cellular mechanisms involved in tissue-specific metabolic modulation by SARS-CoV-2

Santos, Alef Aragão Carneiro dos; Rodrigues, Luiz Eduardo; Alecrim-Zeza, Amanda Lins; Ferreira, Liliane de Araújo; Trettel, Caio dos Santos; Gimenes, Gabriela Mandú; Silva, Adelson Fernandes da; Sousa-Filho, Celso Pereira Batista; Serdan, Tamires Duarte Afonso; Levada‐Pires, Adriana Cristina; Hatanaka, Elaine; Borges, Fernanda Teixeira; Barros, Marcelo Alves; Cury-Boaventura, Maria Fernanda; Bertolini, Gisele Lopes; Cassolla, Priscila; Marzuca‐Nassr, Gabriel Nasri; Vitzel, Kaio Fernando; Pithon‐Curi, Tania Cristina; Masi, Laureane Nunes; Curi, Rui; Gorjão, Renata; Hirabara, Sandro Massao

doi:10.3389/fmicb.2022.1037467

Cited by 8 publications

(4 citation statements)

References 242 publications

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“…Therefore, inflammatory factors play an important role in inhibition of IBV infections ( Zhang et al., 2021 ). The SARS-CoV infection is known to increase the expressions of inflammatory factors, including IL-1, IL-6, and IL-8, and IBV is similar ( Dos Santos et al., 2022 ). Studies have shown that IBV infection is followed by a significant upregulation of the body's inflammatory factors, including IL-1, IL-6, IL-1β, TNF-α, and MIP-1β ( Xiao et al., 2008 ; Liao et al., 2011 ; Dar et al., 2014 ; Zhu et al., 2021 ; Tang et al., 2022 ).…”

Section: Discussionmentioning

confidence: 99%

Radix Isatidis polysaccharide (RIP) resists the infection of QX-type infectious bronchitis virus via the MDA5/TLR3/IRF7 signaling pathway

Xiang¹,

Lv²,

Dong³

et al. 2023

Poultry Science

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Section: Discussionmentioning

confidence: 99%

Radix Isatidis polysaccharide (RIP) resists the infection of QX-type infectious bronchitis virus via the MDA5/TLR3/IRF7 signaling pathway

Xiang¹,

Lv²,

Dong³

et al. 2023

Poultry Science

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“…SARS-CoV-2 may also infect skeletal muscle (Disser et al 2020 ; Santos et al 2022 ), causing musculoskeletal and pain-related symptoms (Mao et al 2020 ). Among these symptoms are fatigue (38%–85%), weakness (approx.…”

Section: Covid-19 Symptoms and Their Relation With Chronic Painmentioning

confidence: 99%

Could the fibromyalgia syndrome be triggered or enhanced by COVID-19?

Fialho

Oliveira

2023

Inflammopharmacol

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Fibromyalgia (FM) is a complex disease with an uncertain aetiology and intricate pathophysiology. Although its genesis is not fully explained, potential environmental factors, such as viral infections might trigger FM or worsen patients' clinical outcomes. The SARS-CoV-2 virus may affect central and peripheral nervous systems, leading to musculoskeletal, neurological, and psychological disturbances. These symptoms might persist at least 12 months beyond the recovery, often referred to as post-COVID syndrome, which resembles FM syndrome. In this sense, we argued the potential consequences of COVID-19 exclusively on FM syndrome. First, we have described post-COVID syndrome and its painful symptoms. Afterwards, we argued whether FM syndrome could be triggered or enhanced by COVID-19 infection or by numerous and persistent stressors imposed daily by the pandemic setting (isolation, uncertainty, depression, mental stress, generalized anxiety, and fear of the virus). In addition, we have demonstrated similarities between pathophysiological mechanisms and cardinal symptoms of FM and COVID-19, speculating that SARS-CoV-2 might represent a critical mediator of FM or an exacerbator of its symptoms once both syndromes share similar mechanisms and complaints. Therefore, pharmacologic and non-pharmacological approaches commonly used to treat FM could serve as strategic therapies to attenuate painful and neurological manifestations of post-COVID syndrome. Although it is still theoretical, clinicians and researchers should be alert of patients who develop symptoms similar to FM or those who had their FM symptoms increased post-COVID to manage them better. Graphical Abstract

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“…[9][10][11][12] In addition, the process of abscess formation may also present a pathophysiological state called a "cytokine storm". 11,13 For example, inflammatory cytokines such as interleukin-10 (IL-10) can induce abscess formation through the mitogen-activated protein kinase (MAPK) pathway. 14 Interleukin-4 (IL-4) can antagonise the effects of IL-10 during infection, 15 attenuate the inflammatory response and promote repair of necrotic tissue by promoting alternative activation of macrophages.…”

Section: Introductionmentioning

confidence: 99%

Construction of a Multi-Indicator Model for Abscess Prediction in Granulomatous Lobular Mastitis Using Inflammatory Indicators

Du,

Feng,

Shao

et al. 2024

JIR

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Background Granulomatous lobular mastitis (GLM) is a chronic inflammatory breast disease, and abscess formation is a common complication of GLM. The process of abscess formation is accompanied by changes in multiple inflammatory markers. The present study aimed to construct a diagnosis model for the early of GLM abscess formation based on multiple inflammatory parameters. Methods Based on the presence or absence of abscess formation on breast magnetic resonance imaging (MRI), 126 patients with GLM were categorised into an abscess group (85 patients) and a non-abscess group (41 patients). Demographic characteristics and the related laboratory results for the 9 inflammatory markers were collected. Logistics univariate analysis and collinearity test were used for selecting independent variables. A regression model to predict abscess formation was constructed using Logistics multivariate analysis. Results The univariate and multivariate analysis showed that the N, ESR, IL-4, IL-10 and INF-α were independent diagnostic factors of abscess formation in GLM ( P <0. 05). The nomogram was drawn on the basis of the logistics regression model. The area under the curve (AUC) of the model was 0.890, which was significantly better than that of a single indicator and the sensitivity and specificity of the model were high (81.2% and 85.40%, respectively). These results predicted by the model were highly consistent with the actual diagnostic results. The results of this calibration curve indicated that the model had a good value and stability in predicting abscess formation in GLM. The decision curve analysis (DCA) demonstrated a satisfactory positive net benefit of the model. Conclusion A predictive model for abscess formation in GLM based on inflammatory markers was constructed in our study, which may provide a new strategy for early diagnosis and treatment of the abscess stage of GLM.

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Molecular and cellular mechanisms involved in tissue-specific metabolic modulation by SARS-CoV-2

Cited by 8 publications

References 242 publications

Radix Isatidis polysaccharide (RIP) resists the infection of QX-type infectious bronchitis virus via the MDA5/TLR3/IRF7 signaling pathway

Radix Isatidis polysaccharide (RIP) resists the infection of QX-type infectious bronchitis virus via the MDA5/TLR3/IRF7 signaling pathway

Could the fibromyalgia syndrome be triggered or enhanced by COVID-19?

Construction of a Multi-Indicator Model for Abscess Prediction in Granulomatous Lobular Mastitis Using Inflammatory Indicators

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