Objective: To compare mean weight, length and head circumference in preterm neonates with zinc supplement group versus without zinc supplement group. Design of the Study: Randomized controlled trial Study Settings: The study was carried out in the Pediatric Department of Lahore General Hospital Lahore from February 2021 to July 2021. Material and Methods: There were two groups of babies: one that received Zinc supplementation and one that did not (not treated with Zinc supplements). An electronic weighing scale was used to measure weight prior to intervention. Mothers were given two bottles of supplement containing zinc when their newborns were 7 to 21 days old, before being discharged from the hospital, and encouraged to feed their babies orally at a dose of 2 mg/kg/day with other multivitamins for six weeks (study group). For the same period of time, the participants in the control group were advised to take only multivitamins. Additionally, anthropometric measurements such as weight, height, and head circumference were taken. Results of the Study: In our study, mean age was calculated as 33.74+1.36 weeks in study and 33.64+1.38 weeks in control group, 54.76%(n=23) in study and 59.52%(n=25) in control group were male while 45.24%(n=19) in study and 40.48%(n=17) in control group were females Conclusion: Preterm neonates supplemented with zinc were significantly better than those without zinc supplementation with regards to mean weight, length and head circumference Keywords: Preterm neonates, zinc supplementation, birthweight, body length, head circumference
Objective: To assess the diagnostic accuracy of serum creatine kinase muscle brain fraction and lactate dehydrogenase for detection of perinatal asphyxia in term neonates using clinical findings as Gold standard Design of the Study: Cross sectional study Study Settings: The study was conducted at Pediatric Department, Lahore General Hospital, Lahore from June 2021 to December 2021. Material and Methods: Demographic information (name, age (in hours), gender, birth weight, and gestational age) was gathered. Under aseptic conditions, blood was taken with a 3cc BD syringe. For CK-MB and LDH testing, samples were sent to the pathology laboratory at the hospital. Two millilitres of clotted blood were tested using reagent kits and auto analyzers. Patients were classified as either positive or negative (according to the operational definition) based on the results of the evaluations of their reports. Results of the Study: In our study, age distribution shows that 63.33%(n=152) were upto 6 hours and 36.67%(n=88) had >6 hours, mean+sd was calculated as 5.60+1.79 hours, 39.17%(n=94) were male and 60.83%(n=146) were females. The diagnostic accuracy of Serum Creatine kinase muscle brain fraction for detection of perinatal asphyxia in term neonates using clinical findings as gold standard was recorded as 93.59% sensitivity, 66.67% specificity, 99.10% positive predictive value, 21.05% negative predictive value and 92.92% accuracy rate. Conclusion: For detecting prenatal asphyxia in term infants, the diagnostic accuracy of serum creatine kinase muscle brain fraction and lactate dehydrogenase (LDH) is useful, however LDH is more accurate than serum creatine kinase muscle brain fraction Keywords: Perinatal asphyxia, detection, diagnostic accuracy
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