S evere acute respiratory syndrome coronavirus 2 (SARS-CoV-2), which produces coronavirus disease (COVID-19), and dengue caused an epidemic in Argentina during 2020. During March 3-October 25, 2020, a total of 1,090,589 confirmed cases of infection with SARS-CoV-2 were reported in this country. Of these cases, 143,990 were reported in Ciudad Autónoma de Buenos Aires (1). During January 4-June 13, 2020, there were ≈7,300 confirmed cases of dengue virus infection in this city (2). Although co-infection with these 2 virus is a major concern, it has only been reported in individual patients (3-5). Information from cohorts of co-infected patients is still lacking. We describe the clinical characteristics and outcomes in a cohort of patients co-infected with SARS-CoV-2 and dengue virus in Buenos Aires. Methods Using a network of colleagues (COVIDENGUE Study Group), we retrospectively identified patients coinfected with SARS-CoV-2 and dengue virus during March-June 2020. Seven sites were in Buenos Aires, and an additional site was in the surrounding area. Through June 30, 2020, healthcare admission was mandated in Argentina for any patient with confirmed COVID-19. Therefore, all patients had complete information regarding signs and symptoms at hospitalization, as well as their hospital course. Clinical data were obtained in a predesigned clinical report form by reviewing medical records. Infection with SARS-CoV-2 was diagnosed by using real-time PCR of nasopharyngeal swab specimens, as approved by the Ministry of Health in reference laboratories. Dengue was diagnosed by either detec
Here we present a survey including 52 drug-naive recently HIV-1-infected subjects from Buenos Aires City and province (79%) and 3 other regions in Argentina (21%). Recent infections were established from previous negative serology (32/52), indeterminate Western blot (12/52), or acute retroviral syndrome after high-risk HIV exposure (8/52) within 9 months before genotyping (median time, 4.2 months). Genotyping was performed from plasma by sequencing both protease and reverse transcriptase. Phylogenetic analysis combined with bootscanning resulted in 21 subtype B sequences and 31 B/F recombinants (RecBF). On protease, minor resistance-related mutations were found in both subtype B and RecBF with low frequencies. The substitution L89M, recently suggested as a resistance-related mutation in some subtype F viruses, was observed in 1 RecBF. On reverse transcriptase, major resistance-related mutations were found in 4 of 52 (7.7%) patients from different health centers: M41L (subtype B) and K103N+/-P225H (1 RecBF and 2 subtype B). The greater than 5% resistance threshold found indicates a need for sentinel resistance surveillances calling for an update in the current resistance testing guidelines in Argentina.
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