Unusual case of plasmablastic Non-Hodgkin’s lymphoma located in the liver. First case reported in an AIDS patient

Metta, Humberto; Corti, Marcelo; Maranzana, Aldo; Schtirbu, Ricardo; Narbaitz, Marina; Soler, Marcela de Dios

doi:10.1016/s1665-2681(19)31773-9

Cited by 10 publications

(2 citation statements)

References 17 publications

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“…[1] in 1987 arising, generally, in the soft tissue of the oral cavity and the jaw in HIVseropositive population. Although PBL presents generally in the oral cavity with local invasion and rapid dissemination to extraoral sites, it has been reported in other sites such as stomach, liver, cervical lymph nodes, lungs, orbit and paranasal sinuses [5][6][7][8][9]. More than 20% of extraoral PBL involve the lymph nodes, as we could see in our patients [10].…”

Section: Discussionsupporting

confidence: 57%

Large abdominal mass as clinical presentation of plasmablastic lymphoma

Corti¹,

Villafañe²,

Boschi³

et al. 2016

Clin Microbiol Infect Dis

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Plasmablastic lymphoma (PBL), a very aggressive variant of diffuse large B cell lymphoma (DLBCL), has been described initially as a rapidly progressive and almost invariably fatal diffuse large-cell lymphoma with plasmablastic features. Immunohistochemical findings showed generally CD20 antigen negative and VS38c, CD138 and MUM 1 positives. This neoplasm was initially described almost exclusively involving the jaw and oral mucosa in HIV-positive patients. However, most recently, the clinical spectrum of the disease has been expanding, with a number of single case reports in HIV-negative patients and with extra-oral manifestations.

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Section: Discussionsupporting

confidence: 57%

Large abdominal mass as clinical presentation of plasmablastic lymphoma

Corti¹,

Villafañe²,

Boschi³

et al. 2016

Clin Microbiol Infect Dis

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“…There have been few reports in the medical literature of cases with extra-oral lesions as we have described in our series. 12–14 Within the oral cavity, gingival and palatal infiltration is characteristic of the PBL subtype.…”

Section: Discussionmentioning

confidence: 99%

Oral cavity and extra-oral plasmablastic lymphomas in AIDS patients: report of five cases and review of the literature

et al. 2011

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Plasmablastic lymphoma (PBL) is a distinct disease entity of the diffuse large B-cell lymphoma, which often occurs in HIV-positive patients. The immunophenotype of this lymphoid neoplasm is characterized by the presence of plasma cell-associated markers VS38c and CD138 antigens and the absence of B-cell markers such as CD20 and CD45. The most frequent site of involvement is the oral cavity and the jaw, while several reports describe the development of PBL in extra-oral sites including the lymph nodes, the anal canal, the soft tissue, the skin and the gastrointestinal tract as less frequent. Epstein-Barr virus is often associated with PBL pathogenesis and the neoplastic cells contain this virus genome. Here we review the epidemiological, clinical, immunological, histopathological and virological characteristics and their prognosis and outcome in a series of five patients with diagnoses of HIV/AIDS and PBL.

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B-Cell Non-Hodgkin’s Lymphomas with a Blastic/Large-Cell Phenotype

Zimmermann¹

2016

Tumors and Tumor-Like Lesions of the Hepatobiliary Tract

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Unusual case of plasmablastic Non-Hodgkin’s lymphoma located in the liver. First case reported in an AIDS patient

Cited by 10 publications

References 17 publications

Large abdominal mass as clinical presentation of plasmablastic lymphoma

Large abdominal mass as clinical presentation of plasmablastic lymphoma

Oral cavity and extra-oral plasmablastic lymphomas in AIDS patients: report of five cases and review of the literature

B-Cell Non-Hodgkin’s Lymphomas with a Blastic/Large-Cell Phenotype

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