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18To study the release of liposome-associated drugs into hydrogels, we designed and hydrogels than the neutral ones. In respect to the ability of the system to handle wound 32 exudates, chitosan-based hydrogels were found to be superior to Carbopol-based hydrogels.

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The effects of mutual saturation of octanol and water on solute partitioning and solubility have been examined. The partition coefficients and solubilities in octanol, water and mutually saturated octanol-water phases were determined for eight antivirus guanine derivatives. Using the Solubility data, enthalpies of fusion (A,,,H) and melting temperatures (Tm), determined by differential scanning calorimetry (DSC), the activity coefficients of the solutes in the aqueous and organic phases were calculated. From these results the intermolecular interactions among the solute and solvent molecules in the aqueous and octanol phases were estimated. It has been shown that the mutual saturation of the octanol and aqueous phases plays an important role in the partitioning of semipoiar substances, such as guanine derivatives.