The effect of lipid composition and liposome size on the release properties of liposomes-in-hydrogel

Hurler, Julia; Žakelj, Simon; Mravljak, Janez; Pajk, Stane; Kristl, Albin; Schubert, Rolf; Škalko‐Basnet, Nataša

doi:10.1016/j.ijpharm.2013.08.033

Cited by 55 publications

(48 citation statements)

References 28 publications

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“…Thus, they developed a moderated PEGylated (size 2 K) multicomponent liposome that hindered protein adsorption but still presented high cellular uptake in cancer cells [74]. Therefore, all of these studies were relevant for the development of efficient biohybrid liposomal pharmaceutical forms, contributing to the elucidation of their performance in the bloodstream [75,76].…”

Section: Liposomesmentioning

confidence: 99%

Advances in Hybrid Polymer-Based Materials for Sustained Drug Release

Ribeiro

Alcántara

Silva

et al. 2017

International Journal of Polymer Science

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The use of biomaterials composed of organic pristine components has been successfully described in several purposes, such as tissue engineering and drug delivery. Drug delivery systems (DDS) have shown several advantages over traditional drug therapy, such as greater therapeutic efficacy, prolonged delivery profile, and reduced drug toxicity, as evidenced by in vitro and in vivo studies as well as clinical trials. Despite that, there is no perfect delivery carrier, and issues such as undesirable viscosity and physicochemical stability or inability to efficiently encapsulate hydrophilic/hydrophobic molecules still persist, limiting DDS applications. To overcome that, biohybrid systems, originating from the synergistic assembly of polymers and other organic materials such as proteins and lipids, have recently been described, yielding molecularly planned biohybrid systems that are able to optimize structures to easily interact with the targets. This work revised the biohybrid DDS clarifying their advantages, limitations, and future perspectives in an attempt to contribute to further research of innovative and safe biohybrid polymer-based system as biomaterials for the sustained release of active molecules.

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Section: Liposomesmentioning

confidence: 99%

Advances in Hybrid Polymer-Based Materials for Sustained Drug Release

Ribeiro

Alcántara

Silva

et al. 2017

International Journal of Polymer Science

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“…The success of dermatotherapy depends also on the properties of the formulation, particularly the spreading ability and retention of the formulation on the skin 18 . Texture analysis was used to evaluate the mechanical properties of the different liposomes-in-vehicle formulations, and parameters such as hardness, adhesiveness and cohesiveness were assessed ( Figure 2).…”

Section: Liposomes-in-vehicle Formulationsmentioning

confidence: 99%

“…Thus, they must be incorporated into a suitable vehicle 14 . In addition to increasing the viscosity and preserving physical stability of conventional liposomes incorporated into hydrogels [15][16][17][18] , dermatological vehicles could affect drug bioavailability and play an important role in the care and maintenance of skin health 2 .…”

Section: Introductionmentioning

confidence: 99%

Elastic liposomes-in-vehicle formulations destined for skin therapy: the synergy between type of liposomes and vehicle

Palac

Hurler

Škalko‐Basnet

et al. 2014

Drug Development and Industrial Pharmacy

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Objective: The present study is focused on optimization of elastic liposomes-in-vehicle formulations in respect to drug release and formulation properties. By combining penetration potential of elastic liposomes containing high ratio of entrapped drug and physicochemical properties of vehicles, both affecting the release and texture properties, optimal formulation could be achieved. Materials and methods:Deformable, propylene glycol-containing or conventional liposomes with hydrophilic model drug (diclofenac sodium) were incorporated into the following vehicles appropriate for skin application: a hydrogel, a cream base and derma membrane structure base cream (DMS base). Each formulation was assessed for in vitro drug release and mechanical properties. Results and discussion:The composition and type of both liposomes and the vehicle affected the rate and amount of the released drug. The cream base exhibited the slowest release, followed by the hydrogel and DMS base. Similar release profiles were achieved with both types of elastic vesicles (deformable and propylene glycol liposomes); the slowest release was observed for conventional liposomes, regardless of the vehicle used. The drug release profiles from different liposomes-in-vehicle formulations were in agreement with the physicochemical properties of the formulations. All of the liposomes were found to be compatible with the hydrogel preserving its original textures, whereas a significant decrease in all texture parameters was observed for liposomes-in-DMS base, regardless of liposome type. Conclusion:Propylene glycol liposomes-in-hydrogel is considered as the optimal formulation for improving skin delivery of hydrophilic drug. Further investigations involving in vivo animal studies are necessary to confirm its applicability in skin therapy. INTRODUCTIONEffective (trans)dermal drug delivery depends on both the selection of an appropriate drug and the properties of the delivery system (vehicle). Vehicles exert pronounced effects on the epidermis, affecting hydration, lubrication, drying, skin smoothness, occlusion and protection.In addition, the physicochemical properties of vehicles influence the pharmacokinetic properties of the incorporated drug by controlling its release from the vehicle and affecting penetration through the stratum corneum, permeation through the layers of skin and absorption into the blood. Preparation and characterization of liposomesDeformable, propylene glycol and conventional liposomes were prepared by the film 6The mean diameters, size distributions (polydispersity) and zeta potentials of the liposomes were determined by photon correlation spectroscopy (Zetasizer 3000HS, MalvernInstruments, Malvern, UK) 20,21 . Membrane elasticity of extruded liposomes was evaluated by home-made device at an external pressure of 5 bar using 100-nm membranes. Detailed procedure with equation for calculation of the deformability degree (E) has been previously described in details 14,19 . Separation of the unentrapped drug was performed usin...

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“…For these reasons, liposomes should be incorporated into suitable vehicles (bases) of appropriate rheological features. The ideal vehicle exhibits appropriate rheological and textural properties, is compatible with both nanosystem and incorporated drug, stable during the storage, and safe to use (Hurler et al, 2013).…”

Section: Introductionmentioning

confidence: 99%

Development and optimization of a new processing approach for manufacturing topical liposomes-in-hydrogel drug formulations by dual asymmetric centrifugation

Ingebrigtsen

Škalko‐Basnet

Holsæter

2016

Drug Development and Industrial Pharmacy

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Objectives: The objective of the present study was to utilize dual asymmetric centrifugation (DAC) as a novel processing approach for the production of liposomes-in-hydrogel formulations. Materials and Methods:Lipid films of phosphatidylcholine, with and without chloramphenicol (CAM), were hydrated and homogenized by DAC to produce liposomes in the form of vesicular phospholipid gels with a diameter in the size range of 200-300 nm suitable for drug delivery to the skin. Different homogenization processing parameters were investigated along with the effect of adding propylene glycol (PG) to the formulations prior to homogenization. The produced liposomes were incorporated into a hydrogel made of 2.5 % (v/v) soluble β-1,3/1,6-glucan (SBG) and mixed by DAC to achieve a homogenous liposomes-inhydrogel-formulation suitable for topical application.Results and Discussion: CAM-containing liposomes with a vesicle diameter of 282 ± 30 nm and polydispersity index (PI) of 0.13 ± 0.02 were successfully produced by DAC after 50 minutes centrifugation at 3500 rpm, and homogenously (< 4 % content variation) incorporated into the SBG hydrogel. Addition of PG decreased the necessary centrifugation time to 2 minutes and 55 seconds, producing liposomes of 230 ± 51 nm and PI of 0.25 ± 0.04. All formulations had an entrapment efficiency of approximately 50%. Conclusions:We managed to develop a relatively fast and reproducible new method for the production of liposomes-in-hydrogel formulation by DAC.

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The effect of lipid composition and liposome size on the release properties of liposomes-in-hydrogel

Abstract: 18To study the release of liposome-associated drugs into hydrogels, we designed and hydrogels than the neutral ones. In respect to the ability of the system to handle wound 32 exudates, chitosan-based hydrogels were found to be superior to Carbopol-based hydrogels.

Cited by 55 publications

References 28 publications

Advances in Hybrid Polymer-Based Materials for Sustained Drug Release

Advances in Hybrid Polymer-Based Materials for Sustained Drug Release

Elastic liposomes-in-vehicle formulations destined for skin therapy: the synergy between type of liposomes and vehicle

Development and optimization of a new processing approach for manufacturing topical liposomes-in-hydrogel drug formulations by dual asymmetric centrifugation

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