Objective: The current study compares the anticoagulant activity of curcumin and ginger rhizome extracts in vitro. Background: Curcuma longa and Zingiber officinale (Ginger) (turmeric, curcuma, or curcumin) Rhizomes are widely used as a spice and in herbal medicine around the world. Methods: To obtain the entire crude extract, Zingiber officinale and Curcuma longa rhizomes were pulverized and extracted in 70% ethanol. The phytochemical contents of the extracts were determined. Their anticoagulant impact was tested in vitro on blood samples from healthy Sudanese people by assessing prothrombin time (PT) and activated partial thromboplastin time (APTT). Results: The ginger extract inhibited coagulation and significantly prolonged prothrombin time (PT) in a dose-dependent manner (25,50, 75 μl) with P. value 0.001, whereas APTT showed insignificant prolongation (P. value 0.139). PT and APTT of curcumin showed insignificant prolongation among (25, 50, 75μl) with P. value 0.55 and 0.146, respectively. Conclusion: The in vitro anticoagulant effect demonstrated that ginger and curcumin extracts had equal anticoagulant activity, but curcumin has a higher anticoagulant impact with considerable PT prolongation. Keywords: Zingiber officinale, Curcuma longa, Coagulation, PT, APTT.
The purpose of this study was to evaluate the anticoagulant activity of Thymus atlanticus leaves. Methods and Results: This cross-sectional study was carried out in Khartoum state from March 2021 to June 2021. This study comprised 60 healthy volunteers (40% men and 60% women) aged 19-25 years. Activated partial thromboplastin time (APTT) and prothrombin time (PT) were evaluated in the blood plasma with different amounts of Thymus atlanticus leaves using Coatron M1 (TECO Medical Devices). Thymus atlanticus leaves considerably lengthened APTT and PT in all tested concentrations. Furthermore, only the APTT test at a concentration of 5.17 μl revealed a significant difference in the anticoagulant activity of Thymus atlanticus leaves between males and females. No correlation between age and anticoagulant activity of Thymus atlanticus leaves on PT and APTT in the study was found.
Background: The most virulent of the human malaria parasites is P. falciparum which is responsible for the bulk of the malaria-related morbidity and mortality. Changes in blood cell parameters are already a well-known feature of malarial infections Aim: The purpose of this research was to assess the total blood count and D-dimer levels in patients with P. falciparum malaria in Khartoum State, Sudan. Study Design: It is case- control study was conducted on blood cells prameters and plasma D-dimer for patients infected with Plasmdium falciparum malaria Place and Duration of Study: study was carried out in Yastabshiroon hospital, Khartoum state, from October 2020 to January 2021. Methodology: The study comprised fifty people who tested positive for P. falciparum using the National Public Health Laboratory's malaria diagnostic standard. The control group consisted of fifty healthy Khartoum locals with about equal gender and age distribution. To collect data from the study group's personal and medical information, such as name, gender, age, and medical condition, a structured questionnaire was developed. Result: D-dimer levels were considerably greater in P. falciparum malaria cases compared to non-falciparum malaria cases, neutrophil and lymphocyte counts were significantly lower, although white blood cells (WBCs) count was significantly lower in P. falciparum infection patients compared to non-falciparum (p≤0.05). Hemoglobin concentration and platelet count were similarly significantly lower (p≤0.05). Platelet counts and mean cell hemoglobin concentration (MCHC), on the other hand, were significantly lower in individuals with severe parasitemia compared to those with low and moderate parasitemia. Conclusion: The study concluded that P. falciparum infection causes considerable hematological alterations. The results of the current investigation revealed a significant increase in the D-dimer mean level, as well as a significant decrease in the count of hemoglobin, total white blood cells (TWBCs), lymphocytes, neutrophils, and platelets. It was also discovered that patients with high parasitemia had considerably lower platelet counts and mean cell hemoglobin concentration (MCHC) levels than those with low and moderate parasitemia.
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