In this study, two experiments had been done: Experiment (1), was designed to determine the acute toxicity of alcoholic extract of coconut ( Cocos nucifera ) fruit to the laboratory mice. Eight groups (6 mice each) of male albino mice were used in this experiment. The first group was drenched (1ml) physiological saline (as control group), while the other seven groups were given orally ascending doses (0.25, 0.5, 1, 1.5, 2, 2.5, 3 g/kg B.W.) respectively. After (24hr), all groups of mice were inspected for the presence of dead mice. The results of this experiment showed no mortality in all groups of mice and the extract is not toxic. Experiment (2), this study was designed to investigate the effect of alcoholic extract of coconut fruit on the efficacy of reproductive system of male mice. For this purpose, (24) mature male mice were allocated equally and randomly into three groups. Group (1) was given physiological saline and was considered as control group. Group (2) and group (3) were given 125mg/kgB.W./day and 200 mg/kg B.W. /day of alcoholic extract of coconut fruit respectively. All mice in the three groups received orally the appropriate treatment for 15 days. Post treatment, two criteria were chosen as indicators for the efficacy of the extract. The first one was relative testicular weight to body weight. The other one was the concentration of sperm in caudal part of epidydemis. The results of this experiment revealed that there was a significant (P<0.01) increase in relative testicular weight/body weight in group that was treated with 125mg/kg/day compared with control group. However, the second group which was treated with 200 mg/kg B.W showed significant decrease in testis weight /body weight as compared to control group and first group.From the present study, one can conclude that the alcoholic extract of Cocos nucifera fruit does not toxic to the laboratory mice and the low dose (125mg/kg B.W.) causes enhancement in male fertility of mice, while higher dose (200mg/kg B.W.) causes reduction Bas. 72in sperm concentration and relative testicular weight/body weight compared with the first dose.

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The study was done to evaluate the antioxidant effects of cinnamon and vitamin C in controlling hyperglycemia and their effect on lipid profile in male rabbits in comparison with the effects of insulin therapy and control animals. Twenty four diabetic rabbits by the injection of alloxan 100 mg/kg body weight in the marginal vein of the ear. These diabetic rabbits were divided randomly into 4 groups Number of animals in each group = 6: Group 1: Was given 2 I.U/ animal of insulin subcutaneously daily. Group 2: Was given ground cinnamon orally 300 mg/kg body weight dissolved in 5 ml normal saline daily. Group 3: Was given vitamin C orally 200 mg/kg body weight dissolved in 5 ml normal saline daily. Group 4: Received orally 5 ml normal saline (0.9% Nacl) daily and considered as control group. All animal groups were treated for five weeks. Blood samples were taken from these groups weekly for biochemical analysis to estimate: Blood glucose, Lipid profile (include total cholesterol (TC), triglyglyceride (TG), high density lipoprotein (HDL), low density lipoprotein (LDL) and very low density lipoprotein(VLDL) and serum malondialdehyde (MDA). The results showed high glucose and lipid concentration associated with an increased oxidant stress alloxan induces on diabetic animals. The statistically analysis showed that a cinnamon and vitamin C significant (P< 0.05) reduction in glucose and lipid profile (TC, TG, HDL, LDL and VLDL) in concordance with a significant elevation in HDL (P<0.05). The level of MDA was also significantly reduced (P<0.05) in all period comparison with period before treated with vit. C and Cinnamon extract. It may conclude that, cinnamon and vitamin C have antioxidant activities to cause an important role in reduction of blood glucose level and lipid profile in hyperglycemic animals.