The lamb meat is a wealth source of proteins (18%-20%), vitamins (thiamine, riboflavin, niacin, pantothenic acid, pyridoxine, and cobalamin), and minerals including iron and phosphorus. Based on existing reports, lamb has a perfect fatty acid composition and contains a lot of long chain unsaturated fatty acids compared to beef (Raes, De Smet, & Demeyer, 2004). This kind of meat is very prone to lipid oxidation during distribution and storage processes. Thus, using an appropriate package can be useful to enhance its safety and shelf life (Camo, Beltrán, & Roncalés, 2008; Karabagias, Badeka, & Kontominas, 2011). Plastics originating from petroleum products (such as polyesters, polyamides) are used extensively in conventional packaging, which is completely non-biodegradable and cause environmental pollution. To this end, the replacement of new packaging systems is considered as an essential requirement in the food packaging industry (Santiago-Silva et al., 2009). Polylactic acid (PLA) is a thermoplastic polyester with a linear chain which is obtained by renewable materials, and lactic acid as its constituent monomer is attained from the fermentation of the basic plant materials such as corn and cassava. PLA is characterized by desirable attributes like transparency and inhibition
The extensive consumption of antibiotics has undesired effects on hosts including high sensitivity, suppressing the immune system, and the allergic reactions in addition to making bacteria resistant. 1,2 The problems raised by resistant bacteria have caused several challenges in the therapeutic system. 2 Nowadays, the spread of Gram-negative pathogens resistant to drugs in hospitals has become a great problem, and is rising in many countrie. 3 Acinetobacter is one of these pathogens which are found in different wards of hospitals, especially in intensive care units (ICUs). The resistance among Acinetobacter spp. has increased dramatically in recent years and has become a global threat. 4 Acinetobacter is one important reason for pneumonia and blood infections in the ICU. 5-7 Currently, it is necessary to find some stronger and more effective antibacterial substance against multi-drug resistant bacteria. 2 From many years ago, medicinal plants have been used for the treatment of different infections. 8 Nowadays, these plants have attracted the attention researchers because of their significant attributes including their strong antibacterial property, being cheap, and accessible. 9,10 One of these medicinal plants which are local in Iran is the shallot (Allium hirtifolium) which has different therapeutic applications. 11 The Iranian shallot is a member of the Allium family and has bulbs (short stem with meaty leaves). This plant is rich in combinations of organosulfur and flavonoids, and due to these combinations it has a strong anti-oxidant and antibacterial activity. Conducted investigations have shown that the aqueous and alcoholic extracts of the stems and the leaves of this plant have a strong antibacterial property. 12-14 The nettle has a long history in treating different diseases and has been used in traditional medicine too. 15 Different studies have revealed that the nettle extract has strong antibacterial
Background: Metal oxide nanoparticles (NPs) have shown promising efficacy for combating bacterial resistance due to their antibacterial properties. This research investigated the effect of zinc oxide NPs (ZnO-NPs) on the antibacterial activity of conventional antibiotics including ciprofloxacin (CIP), cefotaxime (CTX), and colistin (CST) against multidrug-resistant Acinetobacter isolates. Methods: The disc diffusion method was performed to detect the pattern of antibiotic resistance in isolates. The synthesized ZnO-NPs via the solvothermal method were characterized by field emission scanning electron microscopy (FESEM), X-ray diffraction (XRD), and energy-dispersive X-ray spectroscopy (EDS). Finally, the broth microdilution technique was conducted to demonstrate the antibacterial activity of CIP, CTX, and CST antibiotics with and without a sub-inhibitory concentration of ZnO-NPs. Results: XRD, EDS, and FESEM results confirmed the crystalline structure of ZnO-NPs, and the average size was 100±58.68 nm. All isolates were discovered to be of multidrug-resistant (MDR) type and fully susceptible to CST. The antibacterial activity of CTX and CIP was restored when combined with a sub-inhibitory level of ZnO-NPs (0.25 mg/L), and the highest activity was obtained at the concentrations of 32 µg/mL CTX and 8 µg/ mL CIP. Eventually, ZnO-NPs showed a synergistic effect on the antibacterial properties of CST against MDR Acinetobacter. Conclusions: This research indicated that the combination of ZnO-NPs with some common antibiotics can be considered as a novel strategy for reducing the spread of antibiotic-resistant bacteria.
Background and Aim: Wound healing is the result of interactions between cytokines, growth factors, blood, and extracellular matrix. Facing this challenging issue has become one of the essential concerns in health and medical fields, needing different remedies. One of the newest treatments in wound healing is the application of probiotic bacteria. Therefore, the aim of the current study is to evaluate the effect of Bifidobacterium bifidum probiotic bacteria on acute wound healing and exploring the potential of their supernatant on increasing angiogenesis in female mice in the form of biological dressing.Materials and Methods: 44 female BALB/c mice were studied into six groups in two phases of 7 and 14 days. After the wounding process, wound sizes were measured by a digital caliper every 48 hours. Mice were dressed and treated. Histological samples were studied, and the results were analyzed statistically.Results: Bifidobacterium b. probiotic bacteria not only show exciting potential as a therapeutic and effective agent but also our examination proved that application of this probiotic plus Aloe vera hydrogel (experimental group 1) can significantly reduce the wound healing duration and increases angiogenesis (P<0.05).
Conclusion:According to the findings of this study, the designed biological dressing, including Bifidobacterium b. supernatant and Aloe vera hydrogel, can be used in acute wound healing after further studies.
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